Results 141 to 150 of about 572,641 (262)

Interior Decorative VOCs Elevate T Cell‐Mediated Obstructive Lung Disease Risks via Osteogenesis‐Driven Lymphoid‐Biased Hematopoiesis

Advanced Science, EarlyView.
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu, Jingxu Zhang, Qingping Liu, Duxing Li, Ruonan Pan, Gan Miao, Yidi Chen, Zhe Kou, Guangbo Qu, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Frozen Shoulder in Type 2 Diabetes Mellitus

مجله كليه طب الكندي, 2010
Background: Frozen shoulder affects 2-5% of the general population, and around 10-30% of diabetic patients. It affect mainly the non-dominant shoulder, and has more incidence in patients with poor glycemic control.
Atheer Ahmed Matloub, Khalid I. Hussein Al-Lehibi   +1 more
doaj  

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source

Relationship between Glycaemic Burden and Micro- and Macrovascular Complications in Patients with Type 2 Diabetes Mellitus: A real-world study in the Pharmo Database Network [PDF]

, 2015
Jetty A. Overbeek, Rients van Wijngaarden, Joris Diels, A Schubert, Huub Straatman, Hervé Besson, Ewout W. Steyerberg, M. Hemels, Giel Nijpels, Ron M. C. Herings   +9 more
openalex   +1 more source

Diabetes mellitus type 2; an international challenge [PDF]

, 2016
It is of great importance, especially for adults, to keep track of their blood glucose level regularly. It is clear that lifestyle could have a great impact on whether someone develops diabetes or not.
Amiri, Masoud.
core  

NOX2‐Driven Oxidative Stress Promotes EndMT and Uncouples Angiogenesis–Osteogenesis at the Bone–Implant Interface in Diabetes

Advanced Science, EarlyView.
NOX2‐driven oxidative stress disrupts angiogenesis–osteogenesis coupling at the diabetic bone–implant interface. Pharmacologic inhibition and endothelial‐specific NOX2 knockout restore type‐H endothelium, suppress EndMT, and improve osseointegration.
Zimei Wu, Qiaodan Hou, Yang Liu, Tingting Chen, Kunkun Yang, Luyao Li, Lin Wang   +6 more
wiley   +1 more source

Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk

, 2015
Celia G. Walker, Ivonne Solis‐Trapala, Christina Holzapfel, Gina L. Ambrosini, Nicholas R. Fuller, Ruth J. F. Loos, Hans Hauner, Ian D. Caterson, Susan A. Jebb   +8 more
openalex   +2 more sources

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Betatrophin in type 2 diabetes mellitus

Journal of Mahatma Gandhi Institute of Medical Sciences, 2013
Omprakash Gupta
doaj   +1 more source