Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Advanced Science, EarlyView.Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu +9 more
wiley +1 more source
Glycemic Variability and Type 2 Diabetes Mellitus [PDF]
Applied Medical Informatics, 2013 Aim: The purpose of the present study was to quantify glucose variability in type 2 diabetic patients and establishing relationship with cardiometabolic parameters and type of glucose-lowering treatment.
Nicolae HÂNCU +2 more
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Ginsenoside Rg1 Inhibits STAT3 Expression by miR-15b-5p to Attenuate Lung Injury in Mice with Type 2 Diabetes Mellitus-Associated Pulmonary Tuberculosis [PDF]
, 2022 Tingxi Ma +3 more
openalex +1 more source
Type 2 diabetes in Tirana City, Albania: a rapid increase in a country in transition.
, 2004 AIMS: To determine how the prevalence of Type 2 diabetes mellitus has changed in Tirana, the capital of Albania, over 20 years. METHODS: Cluster sampling was used to select 700 households including 1540 adults 25 years of age and over in Tirana City ...
Coker, R, McKee, M, Shapo, L, Ylli, A
core +1 more source
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Nature Reviews Endocrinology, 2023 Georgia Xourafa +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao +5 more
wiley +1 more source
Self-Management Social Support in Type 2 Diabetes Mellitus: A Concept Analysis [PDF]
, 2023 Tariq Al‐Dwaikat +2 more
openalex +1 more source
Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
Development of a Semi-Quantitative Food Frequency Questionnaire to Estimate Macronutrient Intake among Type 2 Diabetes Mellitus Patients in Malaysia [PDF]
, 2023 Norizzati Amsah +2 more
openalex +1 more source
HUBUNGAN LAMA MENDERITA DIABETES MELLITUS TIPE 2 TERHADAP PENURUNAN FUNGSI KOGNITIF PADA PASIEN LANJUT USIA [PDF]
, 2016 ABSTRAKGangguan kognitif sering dijumpai pada penderita Diabetes Mellitus (DM) sebagai akibat dari komplikasi mikrovaskular maupun makrovaskuler. Sampai saat ini studi yang meneliti hubungan lama menderita DM dengan gangguan fungsi kognitif masih ...
Syarifah Sulfira Mulia
core