Results 101 to 110 of about 2,069,243 (304)

Galectin-1 is essential for efficient liver regeneration following hepatectomy [PDF]

, 2016
Galectin-1 (Gal1) is a known immune/inflammatory regulator which actsboth extracellularly and intracellularly, modulating innate and adaptive immuneresponses. Here, we explored the role of Gal1 in liver regeneration using 70% partial hepatectomy (PHx) of
Cerliani, Juan Pablo, Ella, Ezra, Galun, Eithan, Goldenberg, Daniel S., Mizrahi, Lina, Pappo, Orit, Potikha, Tamara, Rabinovich, Gabriel Adrián   +7 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells [PDF]

, 2007
Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis. Studies have established a direct role for nitric oxide (NO) in the regulation of gene expression in mesangial cells.
Banas B., Bannenberg G., Davies M., Gabbai F.B., Guzik T.J., Habib R., Huang S., Hubank M., Ohno M., Rangan G.K., Rosenberg H.G., Stengel B.   +11 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Recent Advances in biological targeted therapies for bronchial asthma (2024)

Allergy Medicine
Bronchial asthma is divided into type 2 and non-type 2 asthma based on the immunopathogenesis. Type 2 inflammation is an inflammation mediated by T helper 2 cells, group 2 innate lymphoid cells and sustained by a specific subset of cytokines.
Nan Su, Bin Cao
doaj   +1 more source

B Cell Activation in Insulin Resistance and Obesity [PDF]

, 2011
Our group has demonstrated that inflammatory diseases such as type 2 diabetes (DM), inflammatory bowel disease (IBD), and periodontal disease (PD) are associated with altered B cell function that may contribute to disease pathogenesis. B cells were found
Apovian, Caroline, Ganley-Leal, Lisa, Gokce, Noyan, Liang, YanMei, McDonnell, Marie, Mehta, Ankeeta, Zhang, Jeanette   +6 more
core   +1 more source

Eicosanoid dysregulation and type 2 inflammation in AERD [PDF]

Journal of Allergy and Clinical Immunology, 2021
Joaquim, Mullol, Joshua, Boyce, Sven-Erik, Dahlén, Barbro, Dahlén, Cesar, Picado, Irina, Bobolea   +5 more
openaire   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma [PDF]

, 2014
Background The mechanisms by which viruses cause asthma exacerbations are not precisely known. Previously, we showed that, in ovalbumin (OVA)-sensitized and -challenged mice with allergic airway inflammation, rhinovirus (RV) infection ...
Bentley, J K, Chen, Qiang, Chung, Yutein, Comstock, Adam T, Goldsmith, Adam M, Hershenson, Marc B, Hong, Jun Y, Lei, Jing, Sajjan, Uma S, Steenrod, Jessica   +9 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source