Results 211 to 220 of about 1,471,209 (258)

IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor. [PDF]

Allergy
Abdu S, Xia J, Yuan H, Tan TJ, Layhadi JA, Shamji MH, McKenzie ANJ, Haloob N, Hopkins C, Woszczek G, Till SJ.   +10 more
europepmc   +1 more source

The clinical and pathological histology efficacy of biological therapy for severe asthma with a phenotype of type 2 inflammation - systematic review. [PDF]

Front Immunol
Ma J, Ma Q, Yang J, Liang P, Zhou J, Ma J, Ma F, Zhuan B, Zhou W.   +8 more
europepmc   +1 more source

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Inflammation and type 2 diabetes

Diabetes & Metabolism, 2012
Low-grade inflammation is a common feature in subjects with type 2 diabetes (T2D). Heart disease, the metabolic syndrome and T2D all have in common the increased concentration of circulatory cytokines as a result of inflammation. Inflammatory cytokines are produced by different cell types and secreted into the circulation, where they regulate different
M C, Calle, M L, Fernandez
openaire   +2 more sources

The emerging role of type 2 inflammation in asthma

Expert Review of Clinical Immunology, 2020
Introduction: Bronchial asthma (BA) is a chronic airways inflammatory disease. Based on the biological mechanisms that underline the disease, asthma has been classified as type 2 or non-type 2 phenotype.Areas covered: An emerging role has been identified for group 2 innate lymphoid cells (ILC2s) able to produce the classical type 2 cytokines.
Andrea Matucci, Susanna Bormioli, Francesca Nencini, Enrico Maggi, Alessandra Vultaggio   +4 more
openaire   +2 more sources

Autoimmune responses and inflammation in type 2 diabetes

Journal of Leukocyte Biology, 2020
Abstract Obesity-induced insulin resistance is one of the largest noncommunicable disease epidemics that we are facing at the moment. Changes in lifestyle and greater availability of low nutritional value, high caloric food has led to the highest rates of obesity in history.
Mukul Prasad, Elijah W. Chen, Sue-Anne Toh, Nicholas R. J. Gascoigne   +3 more
openaire   +2 more sources

Macrophages and islet inflammation in type 2 diabetes

Diabetes, Obesity and Metabolism, 2013
Type 2 diabetes ( T2D ) is characterized by insulin resistance and impaired insulin secretion from pancreatic β‐cells. Inflammatory cytokines, including tumour necrosis factor‐α ( TNF ‐α), have been shown to promote insulin resistance, and altered ...
K, Eguchi, I, Manabe
openaire   +2 more sources

Type 2 airway inflammation in COPD

European Respiratory Journal
Globally, nearly 400 million persons have COPD, and COPD is one of the leading causes of hospitalisation and mortality across the world. While it has been long-recognised that COPD is an inflammatory lung disease, dissimilar to asthma, type 2 inflammation was thought to play a minor role.
Francesca, Polverino, Don D, Sin
openaire   +2 more sources

Inflammation and Type 2 Diabetes

2017
This chapter discusses the current insights into how inflammation, particularly obesity-associated low-grade inflammation, may contribute to development of insulin resistance and β-cell failure, and hence comprise a major culprit for the development of type 2 diabetes. For development of type 2 diabetes, at least two major events are necessary. First,
Van Greevenbroek, Marleen M.J., Schalkwijk, Casper G., Stehouwer, Coen D.A.   +2 more
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Islet Inflammation in Type 2 Diabetes

Diabetes Care, 2008
Decreases in both mass and secretory function of insulin-producing β-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis ...
Marc Y. Donath, Desiree M. Schumann, Mirjam Faulenbach, Helga Ellingsgaard, Aurel Perren, Jan A. Ehses   +5 more
openaire   +1 more source

Mast cells: The Janus of type 2 inflammation

Immunity
Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PGE2)-driven soluble ST2.
Johanna, Kotrba, Anne, Dudeck
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