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Inflammation and Type 2 Diabetes

2017
This chapter discusses the current insights into how inflammation, particularly obesity-associated low-grade inflammation, may contribute to development of insulin resistance and β-cell failure, and hence comprise a major culprit for the development of type 2 diabetes. For development of type 2 diabetes, at least two major events are necessary. First,
Van Greevenbroek, Marleen M.J., Schalkwijk, Casper G., Stehouwer, Coen D.A.   +2 more
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Type 2 airway inflammation in COPD

European Respiratory Journal
Globally, nearly 400 million persons have COPD, and COPD is one of the leading causes of hospitalisation and mortality across the world. While it has been long-recognised that COPD is an inflammatory lung disease, dissimilar to asthma, type 2 inflammation was thought to play a minor role.
Francesca, Polverino, Don D, Sin
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Islet Inflammation in Type 2 Diabetes

Diabetes Care, 2008
Decreases in both mass and secretory function of insulin-producing β-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis ...
Marc Y. Donath, Desiree M. Schumann, Mirjam Faulenbach, Helga Ellingsgaard, Aurel Perren, Jan A. Ehses   +5 more
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Autoimmune responses and inflammation in type 2 diabetes

Journal of Leukocyte Biology, 2020
Abstract Obesity-induced insulin resistance is one of the largest noncommunicable disease epidemics that we are facing at the moment. Changes in lifestyle and greater availability of low nutritional value, high caloric food has led to the highest rates of obesity in history.
Mukul Prasad, Elijah W. Chen, Sue-Anne Toh, Nicholas R. J. Gascoigne   +3 more
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Type 2 Innate Lymphocytes in Allergic Airway Inflammation

Current Allergy and Asthma Reports, 2013
CD4(+) T helper-2 (Th2) cells, which produce a unique profile of IL-4, IL-5 and IL-13 pro-inflammatory cytokines, are thought to be central in the orchestration and amplification of allergic asthma. However, a novel non-T/non-B lymphoid cell population, named type 2 innate lymphocytes (ILC2s), that produces high amounts of IL-5 and IL-13 was recently ...
Klein Wolterink, Roel, Hendriks, Rudi
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Systemic Type 2 Inflammation-Associated Atopic Dermatitis Exacerbates Periodontitis

International Archives of Allergy and Immunology, 2023
<b><i>Introduction:</i></b> Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin disease characterized by Th2 cell-mediated type 2 inflammation. Emerging evidence indicated that AD patients exhibit an increased incidence of oral disorders.
Yuan, Liu, Ziyuan, Wang, Wenting, Jiang, Yinchao, Ma, Haoyan, Wang, Yintong, Xue, Yan, Li, Xiang, Gao, Jie, Hao, Yuedan, Wang, Feng, Chen, Ming, Chu   +11 more
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Macrophages and islet inflammation in type 2 diabetes

Diabetes, Obesity and Metabolism, 2013
Type 2 diabetes ( T2D ) is characterized by insulin resistance and impaired insulin secretion from pancreatic β‐cells. Inflammatory cytokines, including tumour necrosis factor‐α ( TNF ‐α), have been shown to promote insulin resistance, and altered ...
K, Eguchi, I, Manabe
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Cytokine Milieu Tends Toward Inflammation in Type 2 Diabetes

Diabetes Care, 2003
It has been postulated that type 2 diabetes is a manifestation of the inflammatory host response (1). Increased inflammatory activity is believed to play a critical role in development of atherogenesis and to predispose established atherosclerotic plaques to rupture (2). Interleukin (IL)-8 is a potent chemoattractant (chemokine) and induces recruitment
ESPOSITO, Katherine, NAPPO F, GIUGLIANO F, DI PALO C, CIOTOLA M, BARBIERI, Michelangela, PAOLISSO, Giuseppe, GIUGLIANO, Dario   +7 more
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Mast cells: The Janus of type 2 inflammation

Immunity
Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PGE2)-driven soluble ST2.
Johanna, Kotrba, Anne, Dudeck
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The emerging role of type 2 inflammation in asthma

Expert Review of Clinical Immunology, 2020
Introduction: Bronchial asthma (BA) is a chronic airways inflammatory disease. Based on the biological mechanisms that underline the disease, asthma has been classified as type 2 or non-type 2 phenotype.Areas covered: An emerging role has been identified for group 2 innate lymphoid cells (ILC2s) able to produce the classical type 2 cytokines.
Andrea Matucci, Susanna Bormioli, Francesca Nencini, Enrico Maggi, Alessandra Vultaggio   +4 more
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