Results 251 to 260 of about 31,231,377 (293)

Autoimmune responses and inflammation in type 2 diabetes

Journal of Leukocyte Biology, 2020
Abstract Obesity-induced insulin resistance is one of the largest noncommunicable disease epidemics that we are facing at the moment. Changes in lifestyle and greater availability of low nutritional value, high caloric food has led to the highest rates of obesity in history.
Mukul Prasad, Elijah W. Chen, Sue-Anne Toh, Nicholas R. J. Gascoigne   +3 more
openaire   +2 more sources

Inflammation and Type 2 Diabetes

2017
This chapter discusses the current insights into how inflammation, particularly obesity-associated low-grade inflammation, may contribute to development of insulin resistance and β-cell failure, and hence comprise a major culprit for the development of type 2 diabetes. For development of type 2 diabetes, at least two major events are necessary. First,
Van Greevenbroek, Marleen M.J., Schalkwijk, Casper G., Stehouwer, Coen D.A.   +2 more
openaire   +2 more sources

Macrophages and islet inflammation in type 2 diabetes

Diabetes, Obesity and Metabolism, 2013
Type 2 diabetes ( T2D ) is characterized by insulin resistance and impaired insulin secretion from pancreatic β‐cells. Inflammatory cytokines, including tumour necrosis factor‐α ( TNF ‐α), have been shown to promote insulin resistance, and altered ...
K, Eguchi, I, Manabe
openaire   +2 more sources

Mast cells: The Janus of type 2 inflammation

Immunity
Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PGE2)-driven soluble ST2.
Johanna, Kotrba, Anne, Dudeck
openaire   +2 more sources

Islet Inflammation in Type 2 Diabetes

Diabetes Care, 2008
Decreases in both mass and secretory function of insulin-producing β-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis ...
Marc Y. Donath, Desiree M. Schumann, Mirjam Faulenbach, Helga Ellingsgaard, Aurel Perren, Jan A. Ehses   +5 more
openaire   +1 more source

Inflammation, diet, and type 2 diabetes: a mini-review

Journal of Immunoassay and Immunochemistry, 2020
Inflammation is a common feature of type 2 diabetes (T2D). Inflammatory cytokines increase in patients with type 2 diabetes, metabolic syndrome, and heart disease. Various types of cells can produce inflammatory cytokines and then release them into the bloodstream, where their complex interactions with target tissues raise a tissue-specific immune ...
Simin Jafaripour, Sima Sedighi, Mohammad Hassan Jokar, Mehrdad Aghaei, Maliheh Moradzadeh   +4 more
openaire   +2 more sources

The linkage between inflammation and Type 2 diabetes mellitus

Diabetes Research and Clinical Practice, 2013
The Type 2 diabetes mellitus (DM2) is considered nowadays as one of the most important chronic disturbances because of the significant number of people with diabetes and its severe complications, responsible for elevated indexes of morbidity and mortality.
Nathália G, Cruz, Lirlândia P, Sousa, Marinez O, Sousa, Nathalia T, Pietrani, Ana P, Fernandes, Karina B, Gomes   +5 more
openaire   +2 more sources

Osteoprotegerin and biomarkers of vascular inflammation in type 2 diabetes

Diabetes/Metabolism Research and Reviews, 2010
AbstractBackgroundOsteoprotegerin (OPG), receptor activator for nuclear factor kappa beta ligand (RANKL) and tumour necrosis factor–related apoptosis‐inducing ligand (TRAIL) are newly discovered members of the tumour necrosis factor‐alpha receptor superfamily.
O'Sullivan, Eoin P, Ashley, David T, Davenport, Colin, Devlin, Niamh, Crowley, Rachel, Agha, Amar, Thompson, Christopher J, O'Gorman, Donal, Smith, Diarmuid   +8 more
openaire   +3 more sources

The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations

Annals of the American Thoracic Society, 2015
Abstract Asthma exacerbations are an important cause of asthma morbidity. Although viral infection of the upper airway is a common cause of asthma exacerbations, the reasons why some patients with asthma are exacerbation prone and others are exacerbation resistant are not fully understood.
Eleanor M, Dunican, John V, Fahy
openaire   +2 more sources

Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes

Current Diabetes Reports, 2015
At least 2.8 million people die each year as a result of being overweight or obese, and the biggest burden being obesity-related diseases. Overweight and obesity account for a major proportion of type 2 diabetes (T2D) cases. Obesity is associated with inflammation in adipose tissue, namely an infiltration and expansion of macrophages, which produce ...
Ayano, Kohlgruber, Lydia, Lynch
openaire   +2 more sources