Results 91 to 100 of about 31,496,268 (254)

A Ralstonia solanacearum Type III Effector Directs the Production of the Plant Signal Metabolite Trehalose-6-Phosphate

mBio, 2014
The plant pathogen Ralstonia solanacearum possesses two genes encoding a trehalose-6-phosphate synthase (TPS), an enzyme of the trehalose biosynthetic pathway.
M. Poueymiro, A. C. Cazalé, J. M. François, J. L. Parrou, N. Peeters, S. Genin   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Environmental salinity determines the specificity and need for tat-dependent secretion of the YwbN protein in bacillus subtilis [PDF]

, 2011
Twin-arginine protein translocation (Tat) pathways are required for transport of folded proteins across bacterial, archaeal and chloroplast membranes. Recent studies indicate that Tat has evolved into a mainstream pathway for protein secretion in certain
Miethke, Marcus, Theresa Winter, Schaffer Marc, van der Ploeg, René, Jan Maarten van Dijl, Harwood, Colin R., Denham, Emma, Monteferrante, Carmine G., Ulrike Mäder, Marcus Miethke, Maeder, Ulrike, van der Ploeg René, René van der Ploeg, Mohamed A Marahiel, Denham, Emma L., Harwood Colin R., Colin R. Harwood, van Dijl, Jan Maarten, Homuth, Georg, Hecker Michael, Monteferrante Carmine G., Carmine G Monteferrante, Georg Homuth, Mäder Ulrike, Mäder, Ulrike, van Dijl Jan Maarten, Winter Theresa, Emma L. Denham, Homuth Georg, Miethke Marcus, Schaffer, Marc, Michael Hecker, Marahiel Mohamed A., Hecker, Michael, Dijl, Jan Maarten van, Winter, Theresa, Haike Antelmann, Marahiel, Mohamed A., Antelmann, Haike, Antelmann Haike, Carmine G. Monteferrante, Emma L Denham, Denham Emma L., Colin R Harwood, Marc Schaffer, Mohamed A. Marahiel   +45 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genome-wide Investigation of Vibrio parahaemolyticus Type III Secretion System-1 Regulation and Chitin Metabolism

, 2022
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis in humans following the consumption of contaminated seafood, and is a consequential organism for aquaculture and human health.
Getz, Landon John
core  

A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens [PDF]

, 2014
Pathogenic bacteria adapt to their environment and manipulate the biochemistry of hosts by secretion of effector molecules. Serratia marcescens is an opportunistic pathogen associated with healthcare-acquired infections and is a prolific secretor of ...
Guo, Manman, Sargent, Frank, Sarah J. Coulthurst, Buchanan, Grant, Stanley-Wall, Nicola R.; id_orcid, Nicola R. Stanley-Wall, Owen, Richard A., Trost, Matthias, Govind Chandra, Coulthurst, Sarah J.; id_orcid, Matthias Trost, Tracy Palmer, Costa, Marília de Assis Alcoforado, Victoria L. Marlow, Richard A. Owen, Palmer, Tracy, Jaeger J. Hamilton, Hamilton, Jaeger J., Manman Guo, Marlow, Victoria L., Grant Buchanan, Chandra, Govind, Marília de Assis Alcoforado Costa, Frank Sargent   +23 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Large-scale identification of pathogenicity factors in "Bartonella" by signature-tagged mutagenesis [PDF]

, 2005
Bartonellae are bacterial pathogens uniquely adapted to cause intraerythrocytic infection in their mammalian reservoir hosts. In the case of human-specific Bartonella bacilliformis and Bartonella quintana, the intraerythrocytic bacteremia leads to the ...
Saenz Dürrmeier, Luis-Henri
core   +1 more source

pH-responsive substrate switching in mycobacterial type VII ESX secretion

mSphere
During infection, pathogenic mycobacteria reside within phagosomes of varying acidity based on the macrophage activation state. The ESX-1 secretion system (early secreted antigen 6 kilodaltons [ESAT-6] system 1) delivers protein virulence factors ...
Owen A. Collars, Richard L. Hernandez, Simon D. Weaver, Rebecca J. Prest, Caleb Manu, Gopinath Viswanathan, Rachel M. Cronin, Bradley S. Jones, David M. Tobin, Matthew M. Champion, Patricia A. Champion   +10 more
doaj   +1 more source