Results 71 to 80 of about 97,348,975 (279)

Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]

, 2013
Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Redzej, Adam, Topf, Maya, Zechner, E.L., Lang, S., Waksman, Gabriel, Zangger, K., Gruber, C.J., Ilangovan, Aravindan   +7 more
core   +1 more source

The Type 6 Secretion System (T6SS) plays a role in the pathogenesis of strain NMEC15

Microbial Pathogenesis
Neonatal meningitis Escherichia coli (NMEC) is the second leading cause of sepsis and meningitis in newborns with fatality rates of 15-40 %. Survivors may suffer lifelong neurological sequelae such as cerebral palsy, seizures, hearing loss, and delayed development. Despite identification of virulence factors contributing to meningitis, the pathogenesis
Aline L. de Oliveira, Julia Ienes-Lima, Nicolle L. Barbieri, Darby M. Newman, Meaghan M. Young, Lisa K. Nolan, Catherine M. Logue   +6 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Characterization of the SPI-1 and Rsp type three secretion systems in Pseudomonas fluorescens F113 [PDF]

, 2013
Pseudomonas fluorescens F113 is a plant growthpromoting rhizobacterium (PGPR) isolated from the sugar beet rhizosphere. The recent annotation of the F113 genome sequence has revealed that this strain encodes a wide array of secretion systems, including ...
Matthieu Barret, Moynihan, Jennifer, Lesouhaitier, Olivier, Morrissey, John, Egan, Frank, Olivier Lesouhaitier, Morrissey, John P., Frank Egan, John P. Morrissey, Fergal O'Gara, Barret, Matthieu, Jennifer Moynihan, O'Gara, Fergal   +12 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Identification of Possible Virulence Marker from Campylobacter jejuni Isolates

Emerging Infectious Diseases, 2014
A novel protein translocation system, the type-6 secretion system (T6SS), may play a role in virulence of Campylobacter jejuni. We investigated 181 C. jejuni isolates from humans, chickens, and environmental sources in Vietnam, Thailand, Pakistan, and ...
James W. Harrison, Tran Thi Ngoc Dung, Fariha Siddiqui, Sunee Korbrisate, Habib Bukhari, My Phan Vu Tra, Nguyen Van Minh Hoang, Juan Carrique-Mas, Juliet Bryant, James I. Campbell, David J. Studholme, Brendan W. Wren, Stephen Baker, Richard W. Titball, Olivia L. Champion   +14 more
doaj   +1 more source

Characterization and expression analysis of SOLD1, a novel member of the retrotransposon-derived Ly-6 superfamily, in bovine placental villi. [PDF]

PLoS ONE, 2009
BACKGROUND:Ly-6 superfamily members have a conserved Ly-6 domain that is defined by a distinct disulfide bonding pattern between eight or ten cysteine residues. These members are divided into membrane-type and secretory-type proteins.
Koichi Ushizawa, Toru Takahashi, Misa Hosoe, Keiichiro Kizaki, Kazuyoshi Hashizume   +4 more
doaj   +1 more source

The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes [PDF]

, 2010
Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood.
Danchin, Antoine, Philipp Engel, Dehio, Christoph, Quebatte, Maxime, Le Rhun, Danielle, Vayssier-Taussat Muriel, Maxime Quebatte, Saenz, Henri, Lionel Arnaud, Mavris, Arnaud Lionel, Lenaour Evelyne, Yang, Huanming, Sandra Cescau, Wang Jing, Mavris, Maria, Lenaour, Evelyne, Boulouis, Henri Jean, Taussat, Muriel, Antoine Danchin, Vayssier-Taussat, Muriel, Deng Hong Kuan, Jing Wang, Huanming Yang, Boulouis Henri Jean, Arnaud, Lionel, Quebatte Maxime, Engel, Philipp, Le Naour, Evelyne, Muriel Vayssier-Taussat, Henri Saenz, Maria Mavris, Dehio Christoph, Biville Francis, Danielle Le Rhun, Le Rhun Danielle, Danchin Antoine, Francis Biville, Christoph Dehio, Biville, Francis, Geneviève Marignac, Yang Huanming, Engel Philipp, Hong Kuan Deng, Cescau Sandra, Evelyne Lenaour, Mavris Maria, Deng, H.K., Deng, Hong Kuan, Wang, Jing, Marignac Geneviève, Cescau, Sandra, Marignac, Geneviève, Boulouis, Henri-Jean, Henri Jean Boulouis, Arnaud Lionel, Saenz Henri   +55 more
core   +1 more source

Euprymna berryi as a comparative model host for Vibrio fischeri light organ symbiosis

Applied and Environmental Microbiology
Functional studies of host-microbe interactions benefit from natural model systems that enable the exploration of molecular mechanisms at the host-microbe interface.
Avery M. Imes, Morgan N. Pavelsky, Klodia Badal, Derrick L. Kamp, John L. Briseño, Taylor Sakmar, Miranda A. Vogt, Spencer V. Nyholm, Elizabeth A. C. Heath-Heckman, Bret Grasse, Alecia N. Septer, Mark J. Mandel   +11 more
doaj   +1 more source

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

Frontiers in Microbiology, 2019
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through both inner and outer membranes ...
Fernando Navarro-Garcia, Fernando Ruiz-Perez, Ángel Cataldi, Mariano Larzábal   +3 more
doaj   +1 more source