Results 61 to 70 of about 97,348,975 (279)

The central metabolism regulator EIIAGlc switches Salmonella from growth arrest to acute virulence through activation of virulence factor secretion [PDF]

, 2014
The ability of Salmonella to cause disease depends on metabolic activities and virulence factors. Here, we show that a key metabolic protein, EIIAGlc, is absolutely essential for acute infection, but not for Salmonella survival, in a mouse typhoid fever ...
Timo Glatter, Dirk Bumann,, Glatter, T. ; https://orcid.org/, Timo Glatter,, Dirk Bumann, Alain Mazé, Maze, A., Alain Mazé,, Bumann, D., Glatter T, Mazé A, Bumann D   +11 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Structure of a bacterial type IV secretion core complex at subnanometre resolution [PDF]

, 2013
Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of bacteria. They form large multiprotein complexes consisting of 12 proteins termed VirB1-11 and VirD4.
Steyaert, J., Pardon, E, Savva, CG, Lian, Pei W., Fronzes, Remi, Waksman, Gabriel, Orlova, Elena, Orlova, EV, Remaut, Han, Chandran, Vidya, Fronzes, R, Laeremans, T., Chandran, V, Lian, PW, Steyaert, J, Laeremans, T, Rivera-Calzada, A., Remaut, H, Pardon, E., Waksman, G, Rivera-Calzada, A, Savva, Christos G.   +21 more
core   +1 more source

Type VIIb secretion system recruits the dedicated cell wall hydrolase EssH to enable effector secretion by Staphylococcus aureus

mBio
Staphylococcus aureus is a pervasive human pathogen that heavily relies on protein secretion to exert its virulence strategies. S. aureus encodes a specialized type VIIb secretion system (T7SSb) that contributes to virulence and persistence in the host ...
Richard Agyen, Isabelle Powell, Mahalia McNair, Dominique Missiakas, Maksym Bobrovskyy   +4 more
doaj   +1 more source

Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium. [PDF]

PLoS ONE, 2013
Type-6-secretion systems of Gram-negative bacteria are widely distributed needle-like multi-protein complexes that are involved in microbial defense mechanisms.
Juliane Benz, Jochen Reinstein, Anton Meinhart   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Assembly and regulation of the type III secretion system of "Yersinia enterocolitica" [PDF]

, 2010
We investigated the assembly of the Yersinia enterocolitica type III secretion injectisome by grafting fluorescent proteins onto several components, YscC (outer-membrane (OM) ring), YscD (forms the inner-membrane (IM) ring together with YscJ), YscN ...
Diepold, Andreas
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The GacS/GacA two-component system strongly regulates antimicrobial competition mechanisms of Pseudomonas fluorescens MFE01 strain

Journal of Bacteriology
Pseudomonas fluorescens MFE01 is an environmental bacterium characterized by an hyperactive type 6 secretion system (T6SS) and a strong emission of volatile organic compounds (VOCs). In a previous study, a transposition mutant, 3H5, exhibited an inactive
Charly A. Dupont, Yvann Bourigault, Héloïse Biziere-Maco, Amine M. Boukerb, Xavier Latour, Corinne Barbey, Julien Verdon, Annabelle Merieau   +7 more
doaj   +1 more source

Targeting early proximal-rod component substrate FlgB to FlhB for flagellar-type III secretion in Salmonella.

PLoS Genetics, 2022
The Salmonella flagellar secretion apparatus is a member of the type III secretion (T3S) family of export systems in bacteria. After completion of the flagellar motor structure, the hook-basal body (HBB), the flagellar T3S system undergoes a switch from ...
Daofeng Qu, Mengxue Jiang, Calder Duffin, Kelly T Hughes, Fabienne F V Chevance   +4 more
doaj   +1 more source