Results 51 to 60 of about 31,496,268 (254)

Targeting early proximal-rod component substrate FlgB to FlhB for flagellar-type III secretion in Salmonella.

PLoS Genetics, 2022
The Salmonella flagellar secretion apparatus is a member of the type III secretion (T3S) family of export systems in bacteria. After completion of the flagellar motor structure, the hook-basal body (HBB), the flagellar T3S system undergoes a switch from ...
Daofeng Qu, Mengxue Jiang, Calder Duffin, Kelly T Hughes, Fabienne F V Chevance   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structure of a bacterial type IV secretion core complex at subnanometre resolution [PDF]

, 2013
Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of bacteria. They form large multiprotein complexes consisting of 12 proteins termed VirB1-11 and VirD4.
Steyaert, J., Pardon, E, Savva, CG, Lian, Pei W., Fronzes, Remi, Waksman, Gabriel, Orlova, Elena, Orlova, EV, Remaut, Han, Chandran, Vidya, Fronzes, R, Laeremans, T., Chandran, V, Lian, PW, Steyaert, J, Laeremans, T, Rivera-Calzada, A., Remaut, H, Pardon, E., Waksman, G, Rivera-Calzada, A, Savva, Christos G.   +21 more
core   +1 more source

The GacS/GacA two-component system strongly regulates antimicrobial competition mechanisms of Pseudomonas fluorescens MFE01 strain

Journal of Bacteriology
Pseudomonas fluorescens MFE01 is an environmental bacterium characterized by an hyperactive type 6 secretion system (T6SS) and a strong emission of volatile organic compounds (VOCs). In a previous study, a transposition mutant, 3H5, exhibited an inactive
Charly A. Dupont, Yvann Bourigault, Héloïse Biziere-Maco, Amine M. Boukerb, Xavier Latour, Corinne Barbey, Julien Verdon, Annabelle Merieau   +7 more
doaj   +1 more source

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

Frontiers in Microbiology, 2019
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through both inner and outer membranes ...
Fernando Navarro-Garcia, Fernando Ruiz-Perez, Ángel Cataldi, Mariano Larzábal   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]

, 2013
Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Redzej, Adam, Topf, Maya, Zechner, E.L., Lang, S., Waksman, Gabriel, Zangger, K., Gruber, C.J., Ilangovan, Aravindan   +7 more
core   +1 more source

Characterization and expression analysis of SOLD1, a novel member of the retrotransposon-derived Ly-6 superfamily, in bovine placental villi. [PDF]

PLoS ONE, 2009
BACKGROUND:Ly-6 superfamily members have a conserved Ly-6 domain that is defined by a distinct disulfide bonding pattern between eight or ten cysteine residues. These members are divided into membrane-type and secretory-type proteins.
Koichi Ushizawa, Toru Takahashi, Misa Hosoe, Keiichiro Kizaki, Kazuyoshi Hashizume   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes [PDF]

, 2010
Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood.
Danchin, Antoine, Philipp Engel, Dehio, Christoph, Quebatte, Maxime, Le Rhun, Danielle, Vayssier-Taussat Muriel, Maxime Quebatte, Saenz, Henri, Lionel Arnaud, Mavris, Arnaud Lionel, Lenaour Evelyne, Yang, Huanming, Sandra Cescau, Wang Jing, Mavris, Maria, Lenaour, Evelyne, Boulouis, Henri Jean, Taussat, Muriel, Antoine Danchin, Vayssier-Taussat, Muriel, Deng Hong Kuan, Jing Wang, Huanming Yang, Boulouis Henri Jean, Arnaud, Lionel, Quebatte Maxime, Engel, Philipp, Le Naour, Evelyne, Muriel Vayssier-Taussat, Henri Saenz, Maria Mavris, Dehio Christoph, Biville Francis, Danielle Le Rhun, Le Rhun Danielle, Danchin Antoine, Francis Biville, Christoph Dehio, Biville, Francis, Geneviève Marignac, Yang Huanming, Engel Philipp, Hong Kuan Deng, Cescau Sandra, Evelyne Lenaour, Mavris Maria, Deng, H.K., Deng, Hong Kuan, Wang, Jing, Marignac Geneviève, Cescau, Sandra, Marignac, Geneviève, Boulouis, Henri-Jean, Henri Jean Boulouis, Arnaud Lionel, Saenz Henri   +55 more
core   +1 more source