Results 231 to 240 of about 97,348,975 (279)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Increased ADORA1 expression in pancreatic islets coincides with insulin secretory defects in human type 2 diabetes. [PDF]

J Biol Chem
Mohammed Al-Amily I, Parandeh F, Amisten S, Dunér P, Meidute-Abaraviciene S, Grapengiesser E, Hellman B, Salehi A.   +7 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Skeletal Muscle Insulin Resistance in Three Dimensions: Mechanisms, Myokines, and Microphysiological Platform. [PDF]

Cells
Salih M, Bacon J, Johnson SC, Hilgen G, Henstock J, Simoes DCM.   +5 more
europepmc   +1 more source

Biosensor cell array reveals temporal GABA secretion dynamics from pancreatic islets. [PDF]

Mol Metab
Stis AE, Lazimi CS, Ferreira SM, Cuaycal AE, Smurlick D, Hagan DW, Nakayama T, Gandhi SP, Smith E, Spicer TP, Phelps EA.   +10 more
europepmc   +1 more source

Glucagon-Like Peptide-1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications. [PDF]

Pharmacol Res Perspect
Alharbi NHJ.
europepmc   +1 more source

Types I, II, V, and VI secretion system genes in clinical uropathogenic <i>Escherichia coli</i> associate with antibiotic susceptibility, biofilm formation, and persister cells. [PDF]

Microbiol Spectr
Soból P, Kęsek W, Kirzyc M, Podsiadły E, Obrębski M, Skowrońska W, Piwowarski JP, Równicki M.   +7 more
europepmc   +1 more source

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression. [PDF]

Biotechnol J
Vermeulen W, van Staden ADP, Dicks LMT.
europepmc   +1 more source