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Type VI Secretion Effectors: Methodologies and Biology [PDF]

open access: yesFrontiers in Cellular and Infection Microbiology, 2017
The type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative bacteria as a weapon against eukaryotic hosts or prokaryotic competitors.
Yun-Wei Lien   +3 more
doaj   +4 more sources

Macroscopic Quantum-Type Potentials in Theoretical Systems Biology [PDF]

open access: goldCells, 2013
We review in this paper the use of the theory of scale relativity and fractal space-time as a tool particularly well adapted to the possible development of a future genuine systems theoretical biology.
Laurent Nottale
doaj   +5 more sources

Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis [PDF]

open access: goldViruses, 2010
Human T lymphotropic viruses (HTLVs) are complex deltaretroviruses that do not contain a proto-oncogene in their genome, yet are capable of transforming primary T lymphocytes both in vitro and in vivo.
Patrick L. Green, Priya Kannian
doaj   +2 more sources

Antibiotics targeting bacterial protein synthesis reduce the lytic activity of bacteriophages

open access: yesVirus Research, 2022
Combination therapy of bacteriophages and antibiotics requires careful selection of specific antibiotics as it is crucial towards determining the success of phage therapy to treat multiple drug-resistant bacterial infections.
Medhavi Vashisth   +5 more
doaj   +1 more source

Gastric cancer with radiographically occult metastatic disease: Biology, challenges, and diagnostic approaches [PDF]

open access: yes, 2020
Gastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile.
Fangman, Benjamin   +3 more
core   +2 more sources

The biology, function, and biomedical applications of exosomes

open access: yesScience, 2020
Clinical uses of cellular communication Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them.
R. Kalluri, Valerie S. LeBleu
semanticscholar   +1 more source

Bioplastic (poly-3-hydroxybutyrate)-producing Massilia endophytica sp. nov., isolated from Cannabis sativa L. ‘Cheungsam’

open access: yesScientific Reports, 2023
A rod-shaped, motile, Gram-negative bacterial strain named DM-R-R2A-13T was isolated from the plant Cannabis sativa L. ‘Cheungsam’. The phylogenetic analysis of the 16S rRNA gene sequence revealed that strain DM-R-R2A-13T belongs to the family ...
Doeun Jeon   +8 more
doaj   +1 more source

Structure Elucidation and Biochemical Characterization of Environmentally Relevant Novel Extradiol Dioxygenases Discovered by a Functional Metagenomics Approach

open access: yesmSystems, 2019
The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu   +3 more
doaj   +3 more sources

Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2020
Significance Despite clear differences in female and male immunity that may contribute to variations in response to infections and predisposition to cancer and autoimmunity, the exact mechanisms that drive this stark contrast remain insufficiently ...
Sarthak Gupta   +24 more
semanticscholar   +1 more source

NK cell-based cancer immunotherapy: from basic biology to clinical development

open access: yesJournal of Hematology & Oncology, 2021
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK ...
Sizhe Liu   +5 more
semanticscholar   +1 more source

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