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Type VI Secretion Effectors: Methodologies and Biology [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 The type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative bacteria as a weapon against eukaryotic hosts or prokaryotic competitors.
Yun-Wei Lien +3 more
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Macroscopic Quantum-Type Potentials in Theoretical Systems Biology [PDF]
Cells, 2013 We review in this paper the use of the theory of scale relativity and fractal space-time as a tool particularly well adapted to the possible development of a future genuine systems theoretical biology.
Laurent Nottale
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Toward Plant Single Cell Type Systems Biology [PDF]
Frontiers in Plant Science, 2016 The molecular responses of a plant to a stress and the molecular profiles of plant organs during their development and differentiation are the reflection of the contribution from different cell types composing the plant and the organs. Hence, a major limitation to understanding plant cellular and molecular responses in different cells is the ...
Marc eLibault, Sixue eChen
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Single-cell network biology enabling cell-type-resolved disease genetics [PDF]
Genomics & InformaticsGene network models provide a foundation for graph theory approaches, aiding in the novel discovery of drug targets, disease genes, and genetic mechanisms for various biological functions.
Junha Cha, Insuk Lee
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The integrative biology of type 2 diabetes [PDF]
Nature, 2019 Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes remain largely unclear. Insulin resistance, the common underlying abnormality, results from imbalance between energy intake and expenditure favouring nutrient-storage pathways, which evolved to maximize energy utilization and preserve adequate substrate supply to ...
Michael Roden, Gerald I. Shulman
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Guarding the frontiers: the biology of type III interferons [PDF]
Nature Immunology, 2015 Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier tissues. IFN-λs thereby help to maintain healthy mucosal surfaces through immune protection, without
Andreas Wack +2 more
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Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Despite clear differences in female and male immunity that may contribute to variations in response to infections and predisposition to cancer and autoimmunity, the exact mechanisms that drive this stark contrast remain insufficiently ...
Sarthak Gupta +24 more
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Type II-C CRISPR-Cas9 Biology, Mechanism, and Application [PDF]
ACS Chemical Biology, 2017 Genome editing technologies have been revolutionized by the discovery of prokaryotic RNA-guided defense system called CRISPR-Cas. Cas9, a single effector protein found in type II CRISPR systems, has been at the heart of this genome editing revolution ...
Aamir Mir +3 more
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The structural and molecular biology of type III galactosemia [PDF]
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006 Type III galactosemia is a genetic disease caused by mutations in the gene encoding UDP-galactose 4-epimerase. A variety of different point mutations located throughout the gene can be responsible. The main, disease-causing effects of these mutations appear to be a reduction in the catalytic rate constant (kcat) and an increase in the proteolytic ...
David J. Timson
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m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes [PDF]
Nature Metabolism, 2019 The regulation of islet cell biology is critical for glucose homeostasis1. N6-methyladenosine (m6A) is the most abundant internal messenger RNA (mRNA) modification in mammals2. Here, we report that the m6A landscape segregates human type 2 diabetes (T2D)
Dario F. De Jesus +8 more
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