Results 11 to 20 of about 15,925,070 (360)
Guarding the frontiers: the biology of type III interferons [PDF]
Nature Immunology, 2015 Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier ...
A. Wack +2 more
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The integrative biology of type 2 diabetes [PDF]
Nature, 2019 Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes remain largely unclear. Insulin resistance, the common underlying abnormality, results from imbalance between energy intake and expenditure favouring nutrient-storage pathways, which evolved to maximize energy utilization and preserve adequate substrate supply to ...
M. Roden, G. Shulman
semanticscholar +4 more sources
The structural and molecular biology of type III galactosemia [PDF]
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006 Type III galactosemia is a genetic disease caused by mutations in the gene encoding UDP-galactose 4-epimerase. A variety of different point mutations located throughout the gene can be responsible. The main, disease-causing effects of these mutations appear to be a reduction in the catalytic rate constant (kcat) and an increase in the proteolytic ...
David J. Timson
openalex +6 more sources
Structural biology of Type IV secretion system [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2005 Laurent Terradot +4 more
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The biology, function, and biomedical applications of exosomes
Science, 2020 Clinical uses of cellular communication Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them.
R. Kalluri, Valerie S. LeBleu
semanticscholar +1 more source
Gastric cancer with radiographically occult metastatic disease: Biology, challenges, and diagnostic approaches [PDF]
, 2020 Gastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile.
Fangman, Benjamin +3 more
core +2 more sources
NK cell-based cancer immunotherapy: from basic biology to clinical development
Journal of Hematology & Oncology, 2021 Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK ...
Sizhe Liu +5 more
semanticscholar +1 more source
Overview of the biology of type I interferons [PDF]
Arthritis Research & Therapy, 2010 Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be anti-inflammatory and tissue protective or can be proinflammatory and promote autoimmunity.
Lionel B. Ivashkiv +2 more
openaire +2 more sources
Where Do You Get Your Protein? Or: Biochemical Realization [PDF]
, 2020 Biochemical kinds such as proteins pose interesting problems for philosophers of science, as they can be studied from the points of view of both biology and chemistry.
Tahko, Tuomas E.
core +3 more sources
Nutritional systems biology of type 2 diabetes [PDF]
Genes & Nutrition, 2015 Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been recognized as key risk factors for T2D, the underlying mechanisms remain unclear. The advent of nutritional systems biology, a field that aims to
Zhao, Yuqi +2 more
openaire +4 more sources