Results 11 to 20 of about 16,440,357 (384)
The integrative biology of type 2 diabetes [PDF]
Nature, 2019 Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes remain largely unclear. Insulin resistance, the common underlying abnormality, results from imbalance between energy intake and expenditure favouring nutrient-storage pathways, which evolved to maximize energy utilization and preserve adequate substrate supply to ...
M. Roden, G. Shulman
semanticscholar +3 more sources
Toward Plant Single Cell Type Systems Biology [PDF]
Frontiers in Plant Science, 2016 The molecular responses of a plant to a stress and the molecular profiles of plant organs during their development and differentiation are the reflection of the contribution from different cell types composing the plant and the organs. Hence, a major limitation to understanding plant cellular and molecular responses in different cells is the ...
Marc eLibault, Sixue eChen
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Type II-C CRISPR-Cas9 Biology, Mechanism, and Application. [PDF]
ACS Chemical Biology, 2017 Genome editing technologies have been revolutionized by the discovery of prokaryotic RNA-guided defense system called CRISPR-Cas. Cas9, a single effector protein found in type II CRISPR systems, has been at the heart of this genome editing revolution. Nearly half of the Cas9s discovered so far belong to the type II-C subtype but have not been explored ...
Aamir Mir +3 more
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Nutritional systems biology of type 2 diabetes [PDF]
Genes & Nutrition, 2015 Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been recognized as key risk factors for T2D, the underlying mechanisms remain unclear. The advent of nutritional systems biology, a field that aims to
Zhao, Yuqi +2 more
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Where Do You Get Your Protein? Or: Biochemical Realization [PDF]
, 2020 Biochemical kinds such as proteins pose interesting problems for philosophers of science, as they can be studied from the points of view of both biology and chemistry.
Tahko, Tuomas E.
core +3 more sources
Bone Turnover Markers: Basic Biology to Clinical Applications
Endocrine reviews, 2022 Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the last 20 years, much experience has been gained in measurement and interpretation of these markers, which include commonly used bone formation markers (bone ...
M. Schini +4 more
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The cell repair research for Parkinson’s disease: A systematic review
Journal of Neurorestoratology, 2020 Background and Objective:Parkinson’s disease (PD) is a common neurodegenerative disease. Previous studies have demonstrated the effect of cell-based therapies, but their clinical efficacy and safety have not been evaluated.
Chao Chen +7 more
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IMPACT OF SOIL TYPE, BIOLOGY AND TEMPERATURE ON THE SURVIVAL OF NON-TOXIGENIC ESCHERICHIA COLI O157
Biology and Environment: Proceedings of the Royal Irish Academy, 2013 :The occurrence of microbial enteropathogens in the environment can represent a serious risk to human health. The fate of enteropathogens introduced into the soil environment is dependent on a wide range of complex interacting environmental factors ...
E. Moynihan +4 more
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Clinical Biology of the Pituitary Adenoma
Endocrine reviews, 2022 All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and
S. Melmed +12 more
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Structural biology of type VI secretion systems [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2012 Type VI secretion systems (T6SSs) are transenvelope complexes specialized in the transport of proteins or domains directly into target cells. These systems are versatile as they can target either eukaryotic host cells and therefore modulate the bacteria–host interaction and pathogenesis or bacterial cells and therefore facilitate access to a specific ...
Cascales, E., Cambillau, Christian
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