Results 231 to 240 of about 14,138,795 (349)

Protein aggregate or agglomerate: similar punctate structure with distinct biological profiles. [PDF]

Mol Syst Biol
Sun R, Liu Y.
europepmc   +1 more source

The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.

Endocrine reviews, 2011
W. Miller, R. Auchus
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Emergence of supercoiling-mediated regulatory networks through the evolution of bacterial chromosome organization. [PDF]

PLoS Comput Biol
Grohens T, Meyer S, Beslon G.
europepmc   +1 more source

Recent advances in the structural and molecular biology of type IV secretion systems

Current Opinion in Structural Biology, 2014
Martina Trokter, C. Felisberto-Rodrigues, P. Christie, G. Waksman   +3 more
semanticscholar   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Detection of leukemia gene fusions on DNA-level through targeted Next-Generation Sequencing. [PDF]

PLoS One
Chen B, Gao Z, Chen L, Zhang H, Lin Y, Li J.   +5 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Φ -Space: continuous phenotyping of single-cell multi-omics data. [PDF]

Genome Biol
Mao J, Deng Y, Lê Cao KA.
europepmc   +1 more source

Insights into circular RNA biology

RNA Biology, 2017
K. K. Ebbesen, T. B. Hansen, J. Kjems
semanticscholar   +1 more source