Results 231 to 240 of about 15,902,341 (362)

AI-based identification of therapeutic agents targeting GPCRs: introducing ligand type classifiers and systems biology

, 2023
Jonas Goßen, Rui P. Ribeiro, Dirk Bier, Bernd Neumaier, Paolo Carloni, Alejandro Giorgetti, Giulia Rossetti   +6 more
openalex   +2 more sources

Creatine metabolism: energy homeostasis, immunity and cancer biology

Nature Reviews Endocrinology, 2020
L. Kazak, P. Cohen
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Author Correction: SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. [PDF]

Nat Commun
Shao L, Zhou HJ, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W.   +7 more
europepmc   +1 more source

A biology-driven deep generative model for cell-type annotation in cytometry

, 2023
Quentin Blampey, Nadège Bercovici, Charles‐Antoine Dutertre, Isabelle Pic, Joana Ribeiro, Fabrice André, Paul-Henry Cournède   +6 more
openalex   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative. [PDF]

Diabetes
Parent AV, Agarwal A, Alvarez-Dominguez JR, Arrojo E Drigo R, Atkinson MA, Brehm MA, Ferreira LMR, Kaestner KH, Kravets V, Niland JC, O'Meally D, Rouse L, Russ HA, Stabler CL, Kaddis JS.   +14 more
europepmc   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Identifying the DNA methylation preference of transcription factors using ProtBERT and SVM. [PDF]

PLoS Comput Biol
Li Y, Zou Q, Dai Q, Stalin A, Luo X.
europepmc   +1 more source

Telomere biology and metabolic disorders: the role of insulin resistance and type 2 diabetes

, 2020
Е. N. Dudinskaya, О. Н. Ткачева, Н. В. Браилова, И. Д. Стражеско, Marina V. Shestakova   +4 more
openalex   +2 more sources