Results 211 to 220 of about 1,747,398 (243)
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Application of Brønsted-Type LFER in the Study of the Phospholipase C Mechanism
Journal of the American Chemical Society, 2003Phosphatidylinositol-specific phospholipase C cleaves the phosphodiester bond of phosphatidylinositol to form inositol 1,2-cyclic phosphate and diacylglycerol. This enzyme also accepts a variety of alkyl and aryl inositol phosphates as substrates, making it a suitable model enzyme for studying mechanism of phosphoryl transfer by probing the linear free-
Karol S. Bruzik +3 more
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Hydrolysis of surfactant-associated phosphatidylcholine by mammalian secretory phospholipases A2.
American Journal of Physiology - Lung cellular and Molecular Physiology, 1998Hydrolysis of surfactant-associated phospholipids by secretory phospholipases A2 is an important potential mechanism for surfactant dysfunction in inflammatory lung diseases.
R. Hite +5 more
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Phosphatidyl inositol-specific phospholipase C from Clostridium novyi type A
Archives of Biochemistry and Biophysics, 1978Abstract From the culture broth of Clostridium novyi type A, phosphatidyl inositol-specific phospholipase C was separated from the major part of phospholipase C (γ-toxin) which hydrolyzes phosphatidyl choline, phosphatidyl ethanolamine, and sphingomyelin. Sodium deoxycholate stimulated the activity of phosphatidyl inositol phospholipase C.
Hiroh Ikezawa, Ryo Taguchi
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Medicinal research reviews (Print), 2021
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader.
T. Efferth, F. Oesch
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The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader.
T. Efferth, F. Oesch
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Biochemical and Biophysical Research Communications, 1989
The mRNA levels for four types of inositol phospholipid-specific phospholipase C (PLC) in various tissues and cell cultures have been studied by Northern analysis using cDNA probes for PLC isozyme I, II, and III [Sue, P.-G., Ryu, S.H., Moon, K.H., Sue, H.W., and Rhee, S.G. (1988) Proc. Natl. Acad. Sci.
Hiroyuki Sorimachi +4 more
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The mRNA levels for four types of inositol phospholipid-specific phospholipase C (PLC) in various tissues and cell cultures have been studied by Northern analysis using cDNA probes for PLC isozyme I, II, and III [Sue, P.-G., Ryu, S.H., Moon, K.H., Sue, H.W., and Rhee, S.G. (1988) Proc. Natl. Acad. Sci.
Hiroyuki Sorimachi +4 more
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Biochemical and Biophysical Research Communications, 1992
In order to examine physiological function of the SH2/SH3 region of phospholipase C-gamma (Z region), we independently expressed cDNA fragments corresponding to the SH2/SH3 region of PLC-gamma 1 and PLC-gamma 2 in Escherichia coli. Although these recombinant proteins were recovered in particulate fractions by centrifugation of cell extracts, they were ...
Tadaomi Takenawa +2 more
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In order to examine physiological function of the SH2/SH3 region of phospholipase C-gamma (Z region), we independently expressed cDNA fragments corresponding to the SH2/SH3 region of PLC-gamma 1 and PLC-gamma 2 in Escherichia coli. Although these recombinant proteins were recovered in particulate fractions by centrifugation of cell extracts, they were ...
Tadaomi Takenawa +2 more
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The Small GTPase Ral Couples the Angiotensin II Type 1 Receptor to the Activation of Phospholipase C-δ1 [PDF]
Molecular Pharmacology, 2010 The angiotensin II type 1 receptor (AT(1)R) plays an important role in cardiovascular function and as such represents a primary target for therapeutic intervention. The AT(1)R has traditionally been considered to be coupled to the activation of phospholipase C (PLC) beta via its association with G alpha(q/11), leading to increases in intracellular ...
Stephen S. G. Ferguson +5 more
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Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy.
Biochemistry, 2001To investigate the palmitoylation of the human bradykinin B2 receptor, we have mutated individually or simultaneously into glycine two potential acylation sites (cysteines 324 and 329) located in the carboxyl terminus of the receptor and evaluated the ...
A. Pizard +6 more
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Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976A phosphatidylinositol phosphodiesterase from the culture broth of Bacillus cereus, was purified to a homogeneous state as indicated by polyacrylamide gel electrophoresis, by ammonium sulfate precipitation and chromatography with DEAE-cellulose and CM-Sephadex.
Miyashita Tomoyuki +4 more
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Biochemical and Biophysical Research Communications, 1990
A human platelet cytosolic phosphoinositide-specific phospholipase C, one of four PLC activity peaks separated by column chromatographies, designated as cPLC-I, was purified to homogeneity. The cPLC-I exhibited an apparent Mr of 145 kDa by SDS-polyacrylamide gel electrophoresis and was immunologically identified to be PLC-gamma 2.
Yoshinori Nozawa +5 more
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A human platelet cytosolic phosphoinositide-specific phospholipase C, one of four PLC activity peaks separated by column chromatographies, designated as cPLC-I, was purified to homogeneity. The cPLC-I exhibited an apparent Mr of 145 kDa by SDS-polyacrylamide gel electrophoresis and was immunologically identified to be PLC-gamma 2.
Yoshinori Nozawa +5 more
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