Results 211 to 220 of about 275,498 (259)

Structure of equine type I and type II collagens

American Journal of Veterinary Research, 1994
Summary Collagen type I was purified from equine skin and flexor tendon, and type II collagen was purified from equine articular cartilage. The proteoglycans in these tissues were extracted, using guanidine hcl; the collagens were solubilized, using pepsin digestion, then were selectively precipitated with NaCl.
R J, Todhunter, J A, Wootton, G, Lust, R R, Minor   +3 more
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Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage

Matrix Biology, 2006
The objective of this study was to determine whether a fragment(s) of type II collagen can induce cartilage degradation. Fragments generated by cyanogen bromide (CB) cleavage of purified bovine type II collagen were separated by HPLC. These fragments together with selected overlapping synthetic peptides were first analysed for their capacity to induce ...
Tadashi, Yasuda, Elena, Tchetina, Kunitaka, Ohsawa, Peter J, Roughley, William, Wu, Aisha, Mousa, Mirela, Ionescu, Isabelle, Pidoux, A Robin, Poole   +8 more
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Localization of pro-collagen type ii mrna and collagen type ii in the healing tooth socket of the rat

Archives of Oral Biology, 1995
Sprague-Dawley rats (50 days old) were anaesthetized and the maxillary right molars extracted. The rats were killed at 2, 3, 6, 8 and 10 days after extraction. The maxillae were dissected and prepared for either routine histology, in situ hybridization for pro-collagen type II mRNA, or immunohistochemical detection of collagen type II.
Devlin, H.; id_orcid 0000-0002-5120-747X, Hoyland, J., Freemont, A. J.; id_orcid 0000-0002-9780-208X, Sloan, P.   +3 more
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Edaravone suppresses degradation of type II collagen

Biochemical and Biophysical Research Communications, 2016
Osteoarthritis (OA) is a degenerative joint disease affecting millions of people. The degradation and loss of type II collagen induced by proinflammatory cytokines secreted by chondrocytes, such as factor-α (TNF-α) is an important pathological mechanism to the progression of OA.
Chen, Huang, Guangjun, Liao, Jian, Han, Guofeng, Zhang, Benguo, Zou   +4 more
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Type II collagen—induced auricular chondritis

Arthritis & Rheumatism, 1982
AbstractSensitization to type II collagen induced inflammatory destruction of elastic ear cartilage, as well as arthritis, in Sprague—Dawley rats. This auricular lesion morphologically resembled relapsing polychondritis in humans. Moreover, in the experimental model, as has been reported in human disease, extraarticular chondritis occurred in the ...
W J, McCune, A L, Schiller, R A, Dynesius-Trentham, D E, Trentham   +3 more
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Antibodies to Type II Collagen in Relapsing Polychondritis

New England Journal of Medicine, 1978
Relapsing polychondritis is a disorder of unknown cause characterized by the destruction of cartilage. To test the hypothesis that immunologic mechanisms are involved in the pathogenesis of relapsing polychondritis, we analyzed the serum of 15 patients for the presence of antibodies to cartilage. Antibodies to Type II (cartilage) collagen were found in
J M, Foidart, S, Abe, G R, Martin, T M, Zizic, E V, Barnett, T J, Lawley, S I, Katz   +6 more
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Fibromodulin Interactions with Type I and II Collagens

Connective Tissue Research, 2007
Fibromodulin is a keratan-sulfate small leucine-rich proteoglycan (SLRP) regulating collagen I and II fibril formation. In vivo studies suggest that, alongside decorin, fibromodulin plays an important role in the maintenance of mature tissues. To characterize fibromodulin/decorin differences in binding to type I and II collagen, we tested the collagen ...
VIOLA, MANUELA, BARTOLINI BARBARA, SONAGGERE MYRIAM, GIUDICI CAMILLA, TENNI RUGGERO, TIRA M. ENRICA   +5 more
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Type II Collagen Autoimmunity in Rheumatoid Arthritis

The American Journal of the Medical Sciences, 2004
This review summarizes the autoimmune reaction to type II collagen (CII) autoimmunity with regard not only to antibody response to CII but also to the clinical significance or biological characteristics of the CII-reactive T cell, focusing on studies of human RA rather than on animal models.
Wan-Uk, Kim, Mi-La, Cho, Young Ok, Jung, So-Youn, Min, Sung-Whan, Park, Do-Jun, Min, Jong-Hyun, Yoon, Ho-Youn, Kim   +7 more
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Stretching type II collagen with optical tweezers

Journal of Biomechanics, 2004
Collagens are the most abundant proteins of vertebrates and they provide mechanical and supportive functions in a wide range of connective tissues. Knowledge of the mechanical properties of single collagen molecules is essential in studying the self-assembly of collagen, the interaction between cells and extracellular matrix, the etiology of tissue ...
Yu-Long, Sun, Zong-Ping, Luo, Andrzej, Fertala, Kai-Nan, An   +3 more
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Type II collagen screening in the human chondrodysplasias

American Journal of Medical Genetics, 1989
AbstractAbnormalities of type II collagen have been considered strong candidates for causing human chondrody splasias. We have employed peptide mapping to screen for several types of type II collagen abnormalities in cartilage samples from 66 patients with 20 separate disorders. Except for achondrogenesis type II (Langer‐Saldino) and spondyloepiphyseal
W A, Horton, D, Campbell, M A, Machado, J, Chou   +3 more
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