Results 61 to 70 of about 476,925 (305)

Coinvasion of dentinal tubules by Porphyromonas gingivalis and Streptococcus gordonii depends upon binding specificity of streptococcal antigen I/II adhesin [PDF]

, 2000
Cell wall-anchored polypeptides of the antigen I/II family are produced by many species of oral streptococci. These proteins mediate adhesion of streptococci to salivary glycoproteins and to other oral microorganisms and promote binding of cells to ...
Jenkinson, Howard F., Love, Robert M., McMillan, Malcolm D., Park, Yoonsuk   +3 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Type II collagen scaffolds for tissue engineering

Communications Materials
Type II collagen (CII), a key component of cartilaginous tissues, offers an attractive option for fabricating biomimetic scaffolds that provide mechanical support and biochemical signals to facilitate cell adhesion, proliferation, and differentiation ...
Xu Hu, Zhonglian Wu, Zhen Zhang, Hang Yao, Dong-An Wang   +4 more
doaj   +1 more source

Collagen Expression in Various Degenerative Meniscal Changes: An Immunohistological Study

Journal of Orthopaedic Surgery, 2013
Purpose. To examine changes in acid mucopolysaccharides and collagen expression during meniscal degeneration, tearing, and repair, using menisci excised from knee joint surgeries. Methods.
Takatomo Mine, Koichiro Ihara, Hiroyuki Kawamura, Ryo Date, Keitaro Umehara   +4 more
doaj   +1 more source

Substrate elasticity modulates TGF beta stimulated re-differentiation of expanded human articular chondrocytes [PDF]

, 2018
Substrate elasticity has emerged as important biomaterial design parameter. In particular, it has been reported that on soft substrates (~4kPa) freshly isolated porcine chondrocytes better maintain their phenotype than on stiffer ones (>20kPa).
Barbero, Andrea, Gobaa, Samy, Haupt, Olivia, Martin, Ivan, Shastri, V., Trüssel, Andreas, Vonwil, Daniel   +6 more
core  

Effects of serum and compressive loading on the cartilage matrix synthesis and spatiotemporal deposition around chondrocytes in 3D culture [PDF]

, 2013
The aim of this study was to investigate the effects of serum and compressive dynamic loading on the cartilaginous matrix spatiotemporal distribution around chondrocytes in vitro. Murine chondrocytes suspended in agarose were cultured in serum-free media
DeLassus, Elizabeth, Liao, Weiming, Patra, Debabrata, Sandell, Linda J, Wu, Peihui   +4 more
core   +2 more sources

Hybrid bioprinting of chondrogenically induced human mesenchymal stem cell spheroids [PDF]

, 2020
To date, the treatment of articular cartilage lesions remains challenging. A promising strategy for the development of new regenerative therapies is hybrid bioprinting, combining the principles of developmental biology, biomaterial science, and 3D ...
Asadian, Mahtab, De Geyter, Nathalie, De Moor, Lise, Declercq, Heidi, Dubruel, Peter, Fernandez, Sélina, Tytgat, Liesbeth, Van Vlierberghe, Sandra, Vercruysse, Chris   +8 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Performance of new gellan gum hydrogels combined with human articular chondrocytes for cartilage regeneration when subcutaneously implanted in nude mice [PDF]

, 2009
Gellan gum is a polysaccharide that has been recently proposed by our group for cartilage tissueengineering applications. It is commonly used in the food and pharmaceutical industry and has the ability to form stable gels without the use of harsh ...
Andersson, Benya, Cancedda, Cao, Capito, Cortivo, Crawford, Freed, Ge, Girkontaite, Gomes, Grasdalen, Hangody, Hendriks, Hubbell, Hunt, Jackson, Jakob, Kafienah, Kang, Kirsch, Knudson, Langer, Malafaya, Mano, Mao, Mooney, Moroni, Oliveira, Oliveira, Oliveira, Oliveira, Rowley, Sittinger, Temenoff, Tuzlakoglu, Vacanti, Videki, von der Mark, Vunjak-Novakovic   +39 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source