Results 61 to 70 of about 25,865 (227)
Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli [PDF]
, 2017 Escherichia coli that are capable of causing human disease are often classified into pathogenic variants (pathovars) based on their virulence gene content. However, disease-associated hybrid E.
Daugherty, Sean C +6 more
core +2 more sources
Type III secretion system effector proteins are mechanically labile
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The type III secretion system (T3SS) is an important virulence factor that enables some bacteria to directly inject effector proteins into host cells, facilitating colonization. To be secreted, effector proteins must be unfolded, and tightly
M. LeBlanc +3 more
semanticscholar +1 more source
The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA [PDF]
, 2013 Background: Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate
Allison, Sarah E +4 more
core +1 more source
Molecular plant pathology, 2022 A syringe‐like type III secretion system (T3SS) plays essential roles in the pathogenicity of Ralstonia solanacearum, which is a causal agent of bacterial wilt disease on many plant species worldwide.
Min Chen +8 more
semanticscholar +1 more source
Microbiology spectrum, 2022 The increasingly serious problem of bacterial antibiotic resistance limits the clinical application of antibiotics, which increases the need for the development of antivirulence agents.
Yu Shi +9 more
semanticscholar +1 more source
Molecular Plant-Microbe Interactions, 2015 Efficient secretion of type III effector proteins from the bacterial cytoplasm to host cell cytosol via a type III secretion system (T3SS) is crucial for virulence of plant-pathogenic bacterium.
Xiaofeng Zhou +3 more
doaj +1 more source
From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli [PDF]
, 2015 Enterohaemorrhagic Escherichia coli (EHEC) binds to host tissue and intimately attaches to intestinal cells using a dedicated type III secretion system (T3SS). This complex multi-protein organelle is encoded within a large pathogenicity island called the
Connolly, J.P., Finlay, B.B., Roe, A.J.
core +1 more source
Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host. [PDF]
PLoS Pathogens, 2010 Many Gram-negative bacteria colonize and exploit host niches using a protein apparatus called a type III secretion system (T3SS) that translocates bacterial effector proteins into host cells where their functions are essential for pathogenesis.
Colin A Cooper +9 more
doaj +1 more source
Nature Communications, 2019 Many Gram-negative bacteria rely on a type III secretion system (T3SS) for their pathogenicity. Here authors present the cryo-EM structure of the E.coli T3SS ATPase-central stalk complex, which forms a homohexameric, asymmetric pore with different ...
Dorothy D. Majewski +7 more
doaj +1 more source
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mBio, 2011 The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
A. Marijke Keestra +7 more
doaj +1 more source