Charting Endocrine Progenitors Across Species and Organs
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System. [PDF]
Rugge M +4 more
europepmc +1 more source
Important Role of Renin-Angiotensin System and Vasopressin System in Cardiovascular, Metabolic and Psychogenic Disorders in Pregnancy and Early Postnatal Life: A Narrative Review. [PDF]
Szczepańska-Sadowska E.
europepmc +1 more source
Structure-based virulence factor classification using a dual-driven graph transformer with a pretrained language model. [PDF]
Bai P +5 more
europepmc +1 more source
Beyond adaptive immunity: Functional diversity of the type III-A CRISPR-Cas system in <i>Mycobacterium tuberculosis</i>. [PDF]
Yu W, Huang X, Hu Y, Chen S.
europepmc +1 more source
Protein sorting and proteostasis mechanisms in CFTR-related exocrine pancreas dysfunction: A systematic narrative review. [PDF]
Niyomugabo AP +2 more
europepmc +1 more source
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Regulation of type III secretion systems
Current Opinion in Microbiology, 2002Type III secretion systems are utilised by numerous Gram-negative bacteria to efficiently interact with a host. Appropriate expression of type III genes is achieved through the integration of several regulatory pathways that ultimately co-ordinate the activity of a central transcriptional activator usually belonging to the AraC family.
Matthew Francis +2 more
exaly +3 more sources
Type III secretion system (TTSS) is believed to have originally evolved from the flagellar export system and is now dispersed among a number of both animal- and plant-interacting gram-negative bacteria. The aim of much current research on TTSS is to understand the mechanisms involved in effector secretion/injection and what the effectors are doing ...
Gregory V. Plano +2 more
openaire +2 more sources
A Unified Nomenclature for Injectisome-Type Type III Secretion Systems
The independent naming of components of injectisome-type type III secretion systems in different bacterial species has resulted in considerable confusion, impeding accessibility of the literature and hindering communication between scientists of the same field. A unified nomenclature had been proposed by Hueck more than 20 years ago.
Wagner, S., Diepold, A.
openaire +4 more sources
The Structure of the Type III Secretion System Needle Complex
The type III secretion system (T3SS) is an essential virulence factor of many pathogenic bacterial species including Salmonella, Yersinia, Shigella and enteropathogenic Escherichia coli (EPEC). It is an intricate molecular machine that spans the bacterial membranes and injects effector proteins into target host cells, enabling bacterial infection.
Miletic, Sean +2 more
openaire +4 more sources

