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Introduction to Type III Secretion Systems
2016Type III secretion (T3S) systems are found in a large number of gram-negative bacteria where they function to manipulate the biology of infected hosts. Hosts targeted by T3S systems are widely distributed in nature and are represented by animals and plants.
Danielle L Jessen, Condry +1 more
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Type III secretion systems and pathogenicity islands
Journal of Medical Microbiology, 2001Some bacterial pathogens have evolved by acquiring pathogenicity islands (PIs), which are clusters of genes encoding virulence traits. PIs encoding the secretion of effector molecules via type III secretion (TTS) systems have been discovered in several gram-negative pathogens. TTS systems are involved in contact-dependent secretion of virulence factors
Craig, Winstanley, C Anthony, Hart
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Analysis of Type III Secretion System Secreted Proteins
2016Secreted proteins of the T3SS vary from genus to genus. How secretion is induced in vitro also depends on the genus of bacteria. However, once those proteins are isolated the method for analyzing those proteins is largely the same. The following chapter outlines the specific induction of Yersinia secreted proteins and uniform analysis of those secreted
Danielle L Jessen, Condry +1 more
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Expression and Secretion Hierarchy in the Nonflagellar Type III Secretion System
Future Microbiology, 2011Type III secretion systems that deliver bacterial proteins into eukaryotic cells are the basis for both symbiotic and pathogenic relationships between many Gram-negative bacteria and their hosts. Exploration of the structure, function and assembly of this secretion system has greatly enhanced our knowledge of bacterial ecology in the context of ...
Suzanne E, Osborne, Brian K, Coombes
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Lactoferrin disruption of bacterial type III secretion systems
Biometals, 2004Many gram-negative bacteria share a closely related mechanism for secretion of virulence proteins. This complex machine, the type III secretion system, secretes virulence proteins in response to sensing the presence of target mammalian cells. We have found that recombinant human lactoferrin impairs the function of this system in two model organisms ...
Therese J, Ochoa, Thomas G, Clearly
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The Type III Secretion System Sorting Platform
2019A central feature of type III protein secretion machines is their ability to engage their substrates in a hierarchical and organized fashion. The hierarchy in the secretion process is first observed during the assembly of the type III secretion injectisome when the secretion machine exclusively engages proteins required for building the needle complex ...
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The type III secretion system tip complex and translocon
Molecular Microbiology, 2008SummaryThe type III secretion machinery of Gram‐negative bacteria, also known as the injectisome or needle complex, is composed of a basal body spanning both bacterial membranes and the periplasm, and an external needle protruding from the bacterial surface.
Mueller, C. A. +2 more
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Identification of the Targets of Type III Secretion System Inhibitors
2016A type III secretion system (T3SS) Inhibitor can be utilized for study in the research lab but also progressed into drug development. Since many pathogenic Gram-negative bacteria utilize this highly conserved system as a virulence factor, the prospect of the T3SS as a drug target is promising.
Danielle L Jessen, Condry +1 more
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Trends in Genetics, 2001
The bacterial type III secretion pathway delivers effector proteins into eukaryotic cells. Analysis of the type III system and flagellar export genes in the obligate parasites of the family Chlamydiales suggests that the type III system arose from the flagellar export system in chlamydiae or related bacteria.
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The bacterial type III secretion pathway delivers effector proteins into eukaryotic cells. Analysis of the type III system and flagellar export genes in the obligate parasites of the family Chlamydiales suggests that the type III system arose from the flagellar export system in chlamydiae or related bacteria.
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[Progress in type III secretion system].
Wei sheng wu xue bao = Acta microbiologica Sinica, 2009Many Gram-negative bacteria use the type III secretion system (TTSS) to inject toxin proteins into host cells, then cause the plague disease, typhoid fever, diarrhea disease etc. Chaperone proteins is one of four components of MTSS and play an important role in helping the secretion of toxin proteins.
Li, Wang +4 more
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