Direct observation of extension and retraction of type IV pili [PDF]
Proceedings of the National Academy of Sciences, 2001 Type IV pili are thin filaments that extend from the poles of a diverse group of bacteria, enabling them to move at speeds of a few tenths of a micrometer per second. They are required for twitching motility, e.g., in Pseudomonas aeruginosa and Neisseria gonorrhoeae , and for social ...
Skerker, Jeffrey M., Berg, Howard C.
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The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]
, 2016 Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie +2 more
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FrzS regulates social motility in Myxococcus xanthus by controlling exopolysaccharide production. [PDF]
PLoS ONE, 2011 Myxococcus xanthus Social (S) motility occurs at high cell densities and is powered by the extension and retraction of Type IV pili which bind ligands normally found in matrix exopolysaccharides (EPS).
James E Berleman +5 more
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Microbiology Spectrum, 2023 Infections by pathogenic Acinetobacter species represent a significant burden on the health care system, despite their relative rarity, due to the difficulty of treating infections through oral antibiotics.
Nam Vo +3 more
doaj +1 more source
, 2017 A human pathogen, \textit{Neisseria gonorrhoeae} (NG), moves on surfaces by attaching and retracting polymeric structures called Type IV pili. The \textit{tug-of-war} between the pili results in a two-dimensional stochastic motion called \textit ...
Banerjee, Varsha +3 more
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Comparative genomic analysis of Geobacter sulfurreducens KN400, a strain with enhanced capacity for extracellular electron transfer and electricity production [PDF]
, 2012 Peer ...
Aklujkar, Muktak +3 more
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Cell Signaling by the Type IV Pili of Pathogenic Neisseria [PDF]
Journal of Biological Chemistry, 1998 Neisseria gonorrhoeae and Neisseria meningitidis are Gram-negative bacterial pathogens that infect human mucosal epithelia. Type IV pilus-mediated adherence of these bacteria is a crucial early event for establishment of infection. In this work, we show that the type IV pili transduce a signal into the eucaryotic host cell.
H, Källström +3 more
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Characterization of the ATPase FlaI of the motor complex of the Pyrococcus furiosus archaellum and its interactions between the ATP-binding protein FlaH [PDF]
PeerJ, 2018 The archaellum, the rotating motility structure of archaea, is best studied in the crenarchaeon Sulfolobus acidocaldarius. To better understand how assembly and rotation of this structure is driven, two ATP-binding proteins, FlaI and FlaH of the motor ...
Paushali Chaudhury +2 more
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tonB3 is required for normal twitching motility and extracellular assembly of type IV pili [PDF]
, 2004 Three mutants with Tn5-B21 insertion in tonB3 (PA0406) of Pseudomonas aeruginosa exhibited defective twitching motility and reduced assembly of extracellular pili.
Huang, Bixing +4 more
core +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source