Results 21 to 30 of about 10,833,950 (310)

Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization [PDF]

, 2009
A new cyclic nitrone spin trap, [4-(3′,3′-dibutyl-2′-oxy-3′H-isoindol-5′-yloxy)butyl]triphenylphosphonium bromide (MitoSpin), bearing a lipophilic cation has been prepared by a route that involves a novel Parham-type lithiation–cyclization of an ...
Hay, Alison, Hartley, Richard C., Hay, A., Trnka, J., Murphy, M.P., Murphy, Michael P., Quin, Caroline, Trnka, Jan, Hartley, R.C., Quin, C.   +9 more
core   +1 more source

Muscle fiber type-dependent differences in the regulation of protein synthesis. [PDF]

PLoS ONE, 2012
This study examined fiber type-dependent differences in the regulation of protein synthesis in individual muscle fibers found within the same whole muscle.
Craig A Goodman, Jack A Kotecki, Brittany L Jacobs, Troy A Hornberger   +3 more
doaj   +1 more source

Characterization and application of carboxylate-type zwitterions synthesized by one-step

Journal of Ionic Liquids, 2022
Zwitterions have been attracting great attention and the synthesis of carboxylate-type zwitterions is complicated than those of sulfonate-type zwitterions.
Tetsuo Komori, Yui Kato, Kojiro Ishibashi, Kazuaki Ninomiya, Naoki Wada, Daisuke Hirose, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda   +8 more
doaj   +1 more source

Synthesis of Energetic 7-Nitro-3,5-dihydro-4H-pyrazolo[4,3-d][1,2,3]triazin-4-one Based on a Novel Hofmann-Type Rearrangement

Molecules, 2021
Rearrangement reactions are efficient strategies in organic synthesis and contribute enormously to the development of energetic materials. Here, we report on the preparation of a fused energetic structure of 7-nitro-3,5-dihydro-4H-pyrazolo[4,3-d][1,2,3 ...
Fu-Qiang Bi, Yi-Fen Luo, Jun-Lin Zhang, Huan Huo, Bo-Zhou Wang   +4 more
doaj   +1 more source

Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes

Molecules, 2021
GPR120 is a promising target for the treatment of type 2 diabetes (T2DM), which is activated by free fatty acids (FFAs) and stimulates the release of glucagon-like peptide-1(GLP-1).
Guoxia Ji, Qinghua Guo, Qidi Xue, Ruifang Kong, Shiben Wang, Kang Lei, Renmin Liu, Xuekun Wang   +7 more
doaj   +1 more source

RbSyn: type- and effect-guided program synthesis [PDF]

Proceedings of the 42nd ACM SIGPLAN International Conference on Programming Language Design and Implementation, 2021
In recent years, researchers have explored component-based synthesis, which aims to automatically construct programs that operate by composing calls to existing APIs. However, prior work has not considered efficient synthesis of methods with side effects, e.g., web app methods that update a database. In this paper, we introduce RbSyn, a novel type- and
Sankha Narayan Guria, Jeffrey S. Foster, David Van Horn   +2 more
openaire   +3 more sources

A scalable, chromatography-free synthesis of benzotetramisole [PDF]

, 2015
The authors thank the Royal Society for a University Research Fellowship (ADS), the EPSRC (EP/J018139/1, DSBD), and GSK (Case award to SRS) for funding. They also thank the European Research Council under the European Union’s Seventh Framework Programme (
Smith, Siobhan Rose, Smith, Andrew David, Shapland, P., Lebl, Tomas, Daniels, David Sydney Bernard   +4 more
core   +1 more source

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]

, 2004
<b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC, Fabrice MAC Martens, Touyz, R.M., Daigle, Christine, Martens, Fabrice, Touyz Rhian M, Dao Huy, Christine Daigle, Huy Hao Dao, Daphné Girardot, Rhian M Touyz, Moreau Pierre, Girardot, D., Daigle, C., Dao, H., Moreau, P., Girardot, Daphné, Martens, F.M.A.C., Dao, Huy, Daigle Christine, Moreau, Pierre, Girardot Daphné, Pierre Moreau, Touyz, Rhian   +23 more
core   +2 more sources

Large-scale cell-type-specific imaging of protein synthesis in a vertebrate brain

eLife, 2020
Despite advances in methods to detect protein synthesis, it has not been possible to measure endogenous protein synthesis levels in vivo in an entire vertebrate brain.
Or David Shahar, Erin Margaret Schuman
doaj   +1 more source

Parents’ experiences of caring for a young child with type 1 diabetes: a systematic review and synthesis of qualitative evidence

BMC Pediatrics, 2021
Aims To synthesise the qualitative evidence on parents’ experiences of caring for a child aged ≤8 years with type 1 diabetes to identify: the challenges they encounter; their views about support received; ways in which support could be improved; and ...
B. Kimbell, J. Lawton, C. Boughton, R. Hovorka, D. Rankin   +4 more
doaj   +1 more source