Results 41 to 50 of about 11,396,305 (309)
Bicyclic peptides: types, synthesis and applications
Drug Discovery Today, 2019 Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications.
Shahrzad Ahangarzadeh +6 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Synthesis of majucin-type sesquiterpenes and immobilization and visualization of quorum sensing signaling molecules [PDF]
, 2014 The science of chemical biology is the ability to answer biological questions by analyzing living systems at the chemical level. Two entirely different approaches to reach this goal are presented in this thesis.
Gomes, José Rui
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
, 2019 Supplemental material, Supplementary_material_HPO for Children and young people’s experiences and perceptions of self-management of type 1 diabetes: A qualitative meta-synthesis by Ella Tuohy, Caroline Rawdon, Pamela Gallagher, Michele Glacken, Nuala ...
Pamela Gallagher (7309640) +6 more
core +1 more source
Hydrothermal Synthesis of Delafossite-Type Oxides [PDF]
Chemistry of Materials, 2005 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sheets, William C. +4 more
openaire +4 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J
Nature Communications, 2020 Despite being known for more than 50 years, yuzurimine-type alkaloids have not been accessed by total synthesis. Here, the authors report the first enantioselective total synthesis of (+)-Caldaphnidine J, a highly complex yuzurimine-type Daphniphyllum ...
Lian-Dong Guo +6 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Synthesis of Pentapyrazolyl, Pentapyrrolyl, and Pentaanilino C (60) Derivatives
, 2018 Unlike the facile addition of aliphatic amines to fullerenes, heteroaromatic compounds with NH group do not react directly with pristine fullerenes. The present work reports the preparation of several cyclopentadienyl type [60]fullerene derivatives with ...
Kraevaya, Olga A. +3 more
core +1 more source