Results 61 to 70 of about 11,396,305 (309)

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach

Scientific Reports, 2023
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising type of antisense oligonucleotides, but their challenging synthesis makes them difficult to access.
Taiki Tsurusaki, Kazuki Sato, Hiroki Imai, Kunihiro Hirai, Daisuke Takahashi, Takeshi Wada   +5 more
doaj   +1 more source

Introduction of the Evidence synthesis: article type [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2018
With over two million scientific publications appearing each year worldwide, there is an escalating need to access evidence and opinion to inform policy. In response, articles encompassing a breadth of policy and practice, from clinical medicine through to conservation science increasingly adopt an Evidence Synthesis framework.
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Progress, Positivism, and Scientific Revolution: The Synthesis of Darwin's Theory of Evolution [PDF]

Bridging the rift between the sciences and the humanities is important for fostering creativity in all fields of study. Many scientific theories, especially those producing the most profound impact on our understanding of the world, are a continuity of ...
Liu, Yiming
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Type Synthesis of Variable Compression Ratio Engine Mechanisms

Applied Sciences, 2020
Type synthesis of two-degrees-of-freedom (DOF) planar mechanisms has been carried out using graph theory to determine the possible kinematic structures of variable compression ratio (VCR) engine mechanisms with two to three independent loops, and has ...
Young Kwang Mo, Jae Kyung Shim, Seung Woo Kwak, Min Seok Jo, Ho Sung Park   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines

, 2017
A novel Povarov-type reaction for straightforward synthesis of novel spiro bi-tetrahydroquinolines with readily available 1,2-DHQs (1,2-dihydroquinolines) and aromatic imines was developed.
Tang, Z (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China., Wang, WD, Ren, XW, Zhao, G, Huang, J, Zhao, JZ, Zhao, JZ (reprint author), Shanxi Agr Univ Taigu, Coll Art & Sci, Jinzhong 030800, Shanxi, Peoples R China., Zhang, YP, Li, GX, Xing, GM, Gao, CY, Tang, Z   +11 more
core   +1 more source

Overview of evidence synthesis types and modes

Journal of Clinical Epidemiology
Evidence syntheses systematically compile and analyze information from multiple sources to support health-care decision-making. As many different types of questions need to be answered in health care, different evidence synthesis types have emerged.
Barbara Nussbaumer-Streit, Andrew Booth, Chantelle Garritty, Candyce Hamel, Zachary Munn, Andrea C. Tricco, Danielle Pollock   +6 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source