Results 51 to 60 of about 11,396,305 (309)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Vinylepoxides in Organic Synthesis

, 2006
Vinylepoxides have become important intermediates in organic synthesis. The main reason for this is the development of selective methods for their subsequent transformations.
Berit Olofsson, Peter Somfai, Somfai, Peter,, Olofsson, Berit,, Olofsson, B.   +4 more
core   +1 more source

Main-Chain-Type Organoboron Quinolate Polymers:  Synthesis and Photoluminescence Properties

, 2016
Main-Chain-Type Organoboron Quinolate Polymers:  Synthesis and Photoluminescence ...
Yoshiki Chujo (1584643), Yuuya Nagata (1488481)   +1 more
core   +2 more sources

Design and Kinematic Analysis of a Novel Planar Parallel Robot With Pure Translations

IEEE Access
The structural synthesis of a group of parallel mechanisms can be established by an exhaustive enumeration of all feasible kinematic chains based on the screw theory. However, reliable kinematic limbs can provide mobility constraints for some unqualified
Qi Zou, Byung-Ju Yi, Dan Zhang, Yuancheng Shi, Guanyu Huang   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Speaker adaptation and the evaluation of speaker similarity in the EMIME speech-to-speech translation project [PDF]

, 2010
This paper provides an overview of speaker adaptation research carried out in the EMIME speech-to-speech translation (S2ST) project. We focus on how speaker adaptation transforms can be learned from speech in one language and applied to the acoustic ...
Tokuda, Keiichi, Shannon, Matt, Shiota, Sayaka, Wester, Mirjam; id_orcid, Oura, Keiichiro, Gibson, Matthew, Hirsimaki, Teemu, Yamagishi, Junichi, King, Simon; id_orcid, Karhila, Reima, Wu, Yi-Jian, Tian, Jilei, Dines, John, Byrne, William, Saheer, Lakshmi, Liang, Hui, Kurimo, Mikko, Garner, Philip N., Guan, Yong, King, Simon, Wester, Mirjam   +20 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

ELEMENTARY SOLUTIONS OF A HOMOGENEOUS Q-SIDED CONVOLUTION EQUATION

Проблемы анализа, 2018
Spectral synthesis on the complex plane related to solutions of some homogeneous equations of convolution type. There is a method to obtain solutions: we describe the elementary solutions set of the equation (spectral analysis) and prove the ...
Tatarkin A . A ., Saranchuk U . S .   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Type Synthesis of Multi‑mode Parallel Mechanisms Based on Planar Closed‑Loop Chains

Nanjing Hangkong Hangtian Daxue Xuebao
The paper presents a configurational synthesis method for multi-mode parallel mechanisms based on planar closed-loop chains. Firstly， a planar closed-loop chain with two motion modes is introduced.
SUN Hao, ZHENG Zhi, OUYANG Junhong, HU Xiaoxiang, CAO Yi   +4 more
doaj   +1 more source