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The type VI secretion system of Acinetobacter: mechanisms, biology and therapeutic potential. [PDF]

Commun Biol
Jie J, Gu S, Li D, Zhang M, Luo ZQ, Song L.   +5 more
europepmc   +1 more source

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Bacterial Defense against the Type VI Secretion System

Trends in Microbiology, 2021
Bacteria have evolved systems dedicated to interbacterial competition. Here we highlight defenses utilized by Gram-negative cells against type VI secretion system (T6SS)-wielding competitors, including physical barriers, genetically encoded antidotes, and stress responses.
Sophie, Robitaille, Evan, Trus, Benjamin D, Ross   +2 more
openaire   +2 more sources

Type VI secretion system baseplate

Nature Microbiology, 2018
Bacteria employ a specialized weapon known as the type VI secretion system to defend themselves from competing organisms. A new study reveals the molecular architecture of the type VI secretion system and highlights conserved mechanistic similarities with contractile phage tails.
Alan R, Davidson, Karen L, Maxwell
openaire   +2 more sources

Identification of type VI secretion systems in Moritella viscosa

Veterinary Microbiology, 2012
The study describes the identification of type VI secretion systems (T6SSs) in Moritella viscosa, the aetiological agent of winter ulcer disease. Despite the availability of commercial vaccines, M. viscosa causes significant financial losses in salmonid farming.
Bryndis, Bjornsdottir, Erik, Hjerde, Birkir Th, Bragason, Thorunn, Gudmundsdottir, Nils P, Willassen, Bjarnheidur K, Gudmundsdottir   +5 more
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Expression, secretion and bactericidal activity of type VI secretion system in Vibrio anguillarum

Archives of Microbiology, 2016
The type VI secretion system (T6SS) was recently shown to modulate quorum sensing and the stress response in Vibrio anguillarum serotype O1 strain NB10. It is not known whether there is a functionally active T6SS in other serotypes of V. anguillarum. Here, homologues to T6SS cluster VtsEFGH and hemolysin-coregulated protein (Hcp)-encoding genes were ...
Lei, Tang, Shu, Yue, Gui-Yang, Li, Jie, Li, Xiao-Ran, Wang, Shu-Fang, Li, Zhao-Lan, Mo   +6 more
openaire   +2 more sources

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

Nature Reviews Drug Discovery, 2023
P V Kolkhir, Thomas Bieber, E Guttman-Yassky   +2 more
exaly  

Type VII secretion systems: structure, functions and transport models

Nature Reviews Microbiology, 2021
Angel Rivera-Calzada, Nikolaos Famelis, Oscar Llorca   +2 more
exaly  

Targeting inflammation in the treatment of type 2 diabetes: time to start

Nature Reviews Drug Discovery, 2014
Marc Y Donath
exaly  

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

Nature Reviews Drug Discovery, 2011
Frank D Waldron-Lynch, Kevan C Herold
exaly  

Type IV pilus structure and bacterial pathogenicity

Nature Reviews Microbiology, 2004
Lisa Craig, John A Tainer
exaly