Results 101 to 110 of about 16,373,312 (285)

Type VI secretion system sheaths as nanoparticles for antigen display [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Critical aspects that limit use of nanoparticles as vaccine delivery systems include the technical difficulty of preparing particles under conditions that allow controlled protein loading and folding. Biologic nanoparticles offer advantages over chemically derived particles that require harsh organic solvents for ...
Elena, Del Tordello, Olga, Danilchanka, Andrew J, McCluskey, John J, Mekalanos   +3 more
openaire   +2 more sources

A modular effector with a DNase domain and a marker for T6SS substrates

Nature Communications, 2019
Bacteria deliver toxic effectors via type VI secretion systems (T6SSs) to dominate competitors. Here, the authors identify a Vibrio antibacterial effector that contains a new DNase toxin domain and a domain of unknown function that can be used as a ...
Biswanath Jana, Chaya M. Fridman, Eran Bosis, Dor Salomon   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Rules of Engagement: The Type VI Secretion System in Vibrio cholerae [PDF]

Trends in Microbiology, 2017
Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins.
Avatar, Joshi, Benjamin, Kostiuk, Andrew, Rogers, Jennifer, Teschler, Stefan, Pukatzki, Fitnat H, Yildiz   +5 more
openaire   +2 more sources

Recent advances in understanding Pseudomonas aeruginosa as a pathogen [version 1; referees: 3 approved]

F1000Research, 2017
The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen causing acute and chronic infections in predisposed human subjects. Here we review recent progress in understanding P.
Jens Klockgether, Burkhard Tümmler
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Type VI Secretion: Not Just for Pathogenesis Anymore [PDF]

, 2010
Type VI secretion systems (T6SS) have been studied primarily in the context of pathogenic bacteria-host interactions. Recent data suggest, however, that these versatile secretion systems may also function to promote commensal or mutualistic relationships
Cotter, Peggy A., Jani, Andrea J., Andrea J. Jani, Peggy A. Cotter   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Salmonella bongori provides insights into the evolution of the Salmonellae [PDF]

, 2011
The genus Salmonella contains two species, S. bongori and S. enterica. Compared to the well-studied S. enterica there is a marked lack of information regarding the genetic makeup and diversity of S. bongori. S.
Parkhill Julian, Fookes, M, Maskell, Duncan, Caterina Mammina, Kingsley Robert A., Fookes, M., Santiviago, CA, Gad Frankel, Georgios S. Vernikos, Gemma C Langridge, Fookes Maria, Vernikos, G.S., Baeumler, AJ, Mammina, C, Nuccio Sean-Paul, Nastasi, A., Seth-Smith, Helena, Contreras Inés, Langridge, GC, Nuccio, SP, Contreras I, Keith S. Robinson, Schroeder GN, Seth Smith H, Frankel Gad, Humphrey Tom, Petty NK, Nicola K Petty, Sanders, M., Kingsley, Robert A, Dougan G, Kingsley, R.A., Helena Seth-Smith, Baumler, Andreas J., Sanders M, Thomson N.R., Nastasi, A, Gemma C. Langridge, Barrow P, Paul Barrow, Nicholas R Thomson, Seth-Smith, H., Blondel, Carlos J., Santiviago, Carlos A, Frankel, G, Vernikos GS, Seth-Smith Helena, Vernikos, Georgios S., Thomas R. Connor, Vernikos Georgios S., Petty, Nicola K., Petty, N.K., Maskell D, Nuccio, S.-P., Kingsley RA, Humphrey, T., Blondel, Carlos J, Connor, Thomas Richard, Humphrey, Tom, Andreas J. Bäumler, Contreras, I., Vernikos, GS, Robinson, KS, Blondel, C.J., Santiviago, Carlos A., Julian Parkhill, Langridge, Gemma C, Parkhill J, Langridge Gemma C., Blondel CJ, Dougan, Gordon, Georgios S Vernikos, Parkhill, Julian, Barrow, P., Langridge, G.C., Gunnar N Schroeder, Connor TR, Thomas R Connor, Nuccio, Sean, Maskell, D, Roberts Mark, Santiviago CA, Roberts M, Robinson, K.S., Robinson Keith S., Thomson, NR, Santiviago, C.A., Contreras, Ines, Frankel G, Roberts, M., Fookes M, Robert A Kingsley, Sean-Paul Nuccio, Sanders Mandy, Bäumler AJ, Nuccio, S-P, Parkhill, J, Mammina Caterina, Mammina, Caterina, Sanders, M, Mark Roberts, Bäumler Andreas J., Schroeder, Gunnar N., Contreras, I, Connor, T.R., Vernikos, Georgios S, Langridge, Gemma C., Connor Thomas R., Nastasi, Antonino, Gunnar N. Schroeder, Bäumler, AJ, Gordon Dougan, Barrow, P, Robinson, Keith S., Nuccio, Sean-Paul, Maskell Duncan, Sanders, Mandy, Humphrey, T, Carlos A Santiviago, Petty Nicola K., Barrow Paul, Thomson, Nicholas R, Thomson, Nicholas R., Blondel Carlos J., Robinson, Keith S, Keith S Robinson, Seth-Smith, H, Maria Fookes, Nuccio SP, Dougan, G., Inés Contreras, Petty, NK, Schroeder, Gunnar N, Tom Humphrey, Connor, Thomas R, Langridge GC, Frankel, G., Blondel, CJ, Robert A. Kingsley, Maskell, D., Parkhill, J., Dougan Gordon, Thomson Nicholas R., Carlos A. Santiviago, Roberts, Mark, Frankel, Gad, Schroeder Gunnar N., Robinson KS, Santiviago Carlos A., Nicola K. Petty, Petty, Nicola K, Thomas Humphrey, Mandy Sanders, Mammina, C., Kingsley, Robert A., Kingsley, RA, Connor, Thomas R., Barrow, Paul, Nastasi Antonino, Schroeder, GN, Schroeder, G.N., Thomson, N.R., Roberts, M, Nastasi A, Duncan Maskell, Humphrey T, Andreas J Bäumler, Nicholas R. Thomson, Bäumler, A.J., Carlos J Blondel, Connor, TR, Fookes, Maria, Dougan, G, Carlos J. Blondel, Bäumler, Andreas J, Antonino Nastasi   +175 more
core   +3 more sources