Results 91 to 100 of about 16,373,312 (285)

A family of Type VI secretion system effector proteins that form ion-selective pores

Nature Communications, 2019
Type VI secretion systems (T6SSs) are used by bacteria to inject toxic effector proteins into neighbouring cells. Here, Mariano et al. show that an antibacterial effector from Serratia marcescens forms cation-selective pores that lead to inner-membrane ...
Giuseppina Mariano, Katharina Trunk, David J. Williams, Laura Monlezun, Henrik Strahl, Samantha J. Pitt, Sarah J. Coulthurst   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system. [PDF]

, 2010
BACKGROUND: Burkholderia pseudomallei is the causative agent of melioidosis where the highest reported incidence world wide is in the Northeast of Thailand, where saline soil and water are prevalent.
Stabler, Richard A., Sunee Korbsrisate, Stevens, Mark P, Pornpan Pumirat, Ekapot Singsuksawat, Wren, Brendan W, Korbsrisate, Sunee, Singsuksawat, Ekapot, Mark P Stevens, Muangsombut, Veerachat, Veerachat Muangsombut, Cuccui, Jon, Richard A Stabler, Joanne M Stevens, Pumirat, Pornpan, Wren, Brendan W., Stabler, Richard A, Stevens, Joanne M, Stevens, Joanne M.; id_orcid, Stevens, Mark P., Jon Cuccui, Brendan W Wren, Singsuksawat Ekapot, Stevens Mark P, Cuccui Jon, Stabler Richard A, Stevens Joanne M, Korbsrisate Sunee, Wren Brendan W, Muangsombut Veerachat, Pumirat Pornpan   +30 more
core   +1 more source

Abundance of bacterial Type VI secretion system components measured by targeted proteomics

Nature Communications, 2019
Type VI secretion systems (T6SS) are important for bacterial interaction, competition and virulence, but the abundance and assembly of their components is still not well understood.
Lin Lin, Emmanuelle Lezan, Alexander Schmidt, Marek Basler   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Assembly and arrangement of the type three secretion system of "yersinia enterocolitica" [PDF]

, 2014
The type three secretion system (T3SS) is a bacterial weapon found in many Gram-negative bacteria. It consists out of a needle like structure called injectisome, which enables bacteria to inject effector proteins into eukaryotic cells. The injectisome is
Amstutz, Marlise
core   +1 more source

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.

PLoS Pathogens, 2010
Bacteria that live in the environment have evolved pathways specialized to defend against eukaryotic organisms or other bacteria. In this manuscript, we systematically examined the role of the five type VI secretion systems (T6SSs) of Burkholderia ...
Sandra Schwarz, T Eoin West, Frédéric Boyer, Wen-Chi Chiang, Mike A Carl, Rachel D Hood, Laurence Rohmer, Tim Tolker-Nielsen, Shawn J Skerrett, Joseph D Mougous   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes [PDF]

, 2010
Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood.
Danchin, Antoine, Philipp Engel, Dehio, Christoph, Quebatte, Maxime, Le Rhun, Danielle, Vayssier-Taussat Muriel, Maxime Quebatte, Saenz, Henri, Lionel Arnaud, Mavris, Arnaud Lionel, Lenaour Evelyne, Yang, Huanming, Sandra Cescau, Wang Jing, Mavris, Maria, Lenaour, Evelyne, Boulouis, Henri Jean, Taussat, Muriel, Antoine Danchin, Vayssier-Taussat, Muriel, Deng Hong Kuan, Jing Wang, Huanming Yang, Boulouis Henri Jean, Arnaud, Lionel, Quebatte Maxime, Engel, Philipp, Le Naour, Evelyne, Muriel Vayssier-Taussat, Henri Saenz, Maria Mavris, Dehio Christoph, Biville Francis, Danielle Le Rhun, Le Rhun Danielle, Danchin Antoine, Francis Biville, Christoph Dehio, Biville, Francis, Geneviève Marignac, Yang Huanming, Engel Philipp, Hong Kuan Deng, Cescau Sandra, Evelyne Lenaour, Mavris Maria, Deng, H.K., Deng, Hong Kuan, Wang, Jing, Marignac Geneviève, Cescau, Sandra, Marignac, Geneviève, Boulouis, Henri-Jean, Henri Jean Boulouis, Arnaud Lionel, Saenz Henri   +55 more
core   +1 more source