Results 81 to 90 of about 16,373,312 (285)

The evolution of the type VI secretion system as a disintegration weapon

PLOS Biology, 2020
The type VI secretion system (T6SS) is a nanomachine used by many bacteria to drive a toxin-laden needle into other bacterial cells. Although the potential to influence bacterial competition is clear, the fitness impacts of wielding a T6SS are not well understood.
Smith, WPJ, Vettiger, A, Winter, J, Ryser, T, Comstock, LE, Basler, M, Foster, KR   +6 more
openaire   +6 more sources

Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin

Nature Communications, 2021
Rearrangement hot spots (Rhs) proteins are bacterial polymorphic toxin systems. Here, the authors show that Rhs1 forms a complex with the Type VI secretion system (T6SS) spike protein VgrG and the EagR chaperone.
Dukas Jurėnas, Leonardo Talachia Rosa, Martial Rey, Julia Chamot-Rooke, Rémi Fronzes, Eric Cascales   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Structural and Functional Insights into the Pilotin-Secretin Complex of the Type II Secretion System [PDF]

, 2012
PMCID: PMC3276575This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Rehman Saima, Shuang Gu (184317), Rehman, S., Richard W Pickersgill, Pickersgill, R. W., Gu, S, Gu, S., Shuang Gu, Shevchik Vladimir E., Shevchik, V. E., Shevchik, VE, Pickersgill, RW, Wang, X., Wang, X, Vladimir E Shevchik, Xiaohui Wang (19899), Xiaohui Wang, Rehman, S, Vladimir E. Shevchik (184325), Gu Shuang, Pickersgill Richard W., Saima Rehman (184320), Richard W. Pickersgill (87514), Shevchik, Vladimir, Saima Rehman, Wang Xiaohui   +25 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

TssA: The cap protein of the Type VI secretion system tail [PDF]

BioEssays, 2017
The Type VI secretion system (T6SS) is a multiprotein and mosaic apparatus that delivers protein effectors into prokaryotic or eukaryotic cells. Recent data on the enteroaggregative Escherichia coli (EAEC) T6SS have provided evidence that the TssA protein is a key component during T6SS biogenesis.
Zoued, Abdelrahim, Durand, Eric, Santin, Yoann, Journet, Laure, Roussel, Alain, Cambillau, Christian, Cascales, E.   +6 more
openaire   +4 more sources

Collective protection against the type VI secretion system in bacteria

The ISME Journal, 2022
Abstract Bacteria commonly face attacks from other strains using the type VI secretion system (T6SS), which acts like a molecular speargun to stab and intoxicate competitors. Here we show how bacteria can work together to collectively defend themselves against these attacks.
Elisa T. Granato, William P. J. Smith, Kevin R. Foster   +2 more
openaire   +4 more sources