Results 121 to 130 of about 16,373,312 (285)

The Type VI secretion systems of the insect pathogen Photorhabdus luminescens are involved in interbacterial competition, motility and secondary metabolism

The Microbe
The Type VI Secretion System (T6SS) is used as weapon by a variety of Gram-negative bacteria in polymicrobial niche competition. Its characterization and study gained more interest in recent years.
Friederike Pisarz, Timo Glatter, Dhana-Theresa M. Süss, Ralf Heermann, Alice Regaiolo   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. [PDF]

, 2009
Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for severe gastric diseases, including gastric cancer.
Haas, Rainer, Rainer Haas, Kapp, Ulrike, Jung, Kirsten, Kirsten Jung, Rohde, Manfred, Claudia Ertl, Retta, S. Francesco, S. Francesco Retta, Terradot Laurent, Ertl, Claudia, Luisa F. Jiménez-soto, Luisa F Jiménez-Soto, Fischer Rainer Haas, Retta S. Francesco, Pirch Torsten, Weiss, Evelyn, Xaver Sewald, Jiménez-Soto Luisa F., Wolfgang Fischer, Ertl Claudia, Evelyn Weiss, Jiménez-Soto, Luisa F., Fischer, Wolfgang, Weiss Evelyn, Manfred Rohde, Kutter, Stefan, Kutter Stefan, Pirch, Torsten, Terradot, Laurent, Sewald, Xaver, Fischer Wolfgang, Torsten Pirch, Laurent Terradot, S Francesco Retta, Haas Rainer, Rohde Manfred, Kapp Ulrike, Ulrike Kapp, Retta, Saverio Francesco, Stefan Kutter, Jung Kirsten, Sewald Xaver   +42 more
core   +2 more sources

Structure of the type VI secretion system TssK–TssF–TssG baseplate subcomplex revealed by cryo-electron microscopy

Nature Communications, 2018
Type VI secretion systems (T6SSs) translocate effector proteins into eukaryotic and bacterial recipient cells and are present in many Gram-negative bacteria.
Young-Jun Park, Kaitlyn D. Lacourse, Christian Cambillau, Frank DiMaio, Joseph D. Mougous, David Veesler   +5 more
doaj   +1 more source

Secretion systems and signal exchange between nitrogen-fixing rhizobia and legumes

Frontiers in Plant Science, 2015
The formation of symbiotic nitrogen-fixing nodules on the roots and/or stem of leguminous plants involves a complex signal exchange between both partners. Since many microorganisms are present in the soil, legumes and rhizobia must recognize and initiate
Matthew S Nelson, Michael J Sadowsky
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Type VI secretion system regulation as a consequence of evolutionary pressure

Journal of Medical Microbiology, 2013
The type VI secretion system (T6SS) is a mechanism evolved by Gram-negative bacteria to negotiate interactions with eukaryotic and prokaryotic competitors. T6SSs are encoded by a diverse array of bacteria and include plant, animal, human and fish pathogens, as well as environmental isolates.
Sarah T, Miyata, Verena, Bachmann, Stefan, Pukatzki   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Type VI secretion system: a versatile bacterial weapon

Microbiology, 2019
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-negative bacteria and is used to translocate effector proteins directly into neighbouring cells. It represents a versatile bacterial weapon that can deliver effectors into distinct classes of target cells, playing key roles in inter-bacterial competition and ...
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source