Results 41 to 50 of about 33,313 (146)
Tagging the type VI secretion system [PDF]
Nature Microbiology, 2018 Bacteria use multiple mechanisms to secrete proteins across their envelope and gain access to resources in their niche. The type VI secretion system (T6SS) specializes in injecting toxic protein effectors by direct contact, killing the target eukaryotic or bacterial cells1.
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Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system
Nature Communications, 2020 Bacterial Rhs proteins with toxic domains are often secreted by type VI secretion systems. Here, the authors show that one of these proteins self-cleaves into three fragments, with the Rhs core and the N-terminal domain facilitating secretion and ...
Tong-Tong Pei +11 more
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Type VI secretion system: secretion by a contractile nanomachine [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2015 The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. Several key components of T6SS are evolutionarily related to components of contractile nanomachines such as phages and R-type pyocins. The T6SS assembly is initiated by formation of a membrane complex that binds a phage-like baseplate with a sharp spike ...
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mSystems, 2021 Antagonistic interactions between bacteria affect diversity and dynamics of host-associated communities, including gut communities that are linked to host health. In many bacterial communities, including human and honey bee gut microbiotas, antagonism is
Margaret I. Steele, Nancy A. Moran
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Characterization of Type VI secretion system in Edwardsiella ictaluri
PLOS ONE, 2023 Edwardsiella ictaluri is a Gram-negative facultative intracellular fish pathogen causing enteric septicemia of catfish (ESC). While various secretion systems contribute to E. ictaluri virulence, the Type VI secretion system (T6SS) remains poorly understood. In this study, we constructed 13 E.
Safak Kalindamar +5 more
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Structure and Activity of the Type VI Secretion System [PDF]
Microbiology Spectrum, 2019 ABSTRACT The type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like mechanism to inject effectors into target cells. The injection apparatus is composed of a baseplate on which is built a contractile tail tube/sheath complex.
Cherrak, Yassine +4 more
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The type VI secretion system: a tubular story [PDF]
The EMBO Journal, 2009 The molecular mechanism by which proteins are secreted in gram-negative bacteria is supported by nanomachines called type I to type VI secretion systems (T1SS to T6SS). Previous data suggested that the ClpV ATPase energizes the transport of Hcp and VgrG proteins through the T6SS secretion channel.
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Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties
Nature Communications, 2021 Bacteria can use type VI secretion systems (T6SSs) to inject toxic effector proteins into adjacent cells, in a contact-dependent manner. Here, the authors provide evidence of contact-independent killing by a T6SS effector that is secreted into the ...
Li Song +11 more
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The rise of the Type VI secretion system [PDF]
F1000Prime Reports, 2013 Bacterial cells have developed multiple strategies to communicate with their surrounding environment. The intracellular compartment is separated from the milieu by a relatively impermeable cell envelope through which small molecules can passively diffuse, while larger macromolecules, such as proteins, can be actively transported.
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PLoS Pathogens, 2014 The type VI secretion system (T6SS) is a widespread protein secretion system found in many Gram-negative bacteria. T6SSs are highly regulated by various regulatory systems at multiple levels, including post-translational regulation via threonine (Thr ...
Jer-Sheng Lin +6 more
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