Results 41 to 50 of about 16,373,312 (285)
Structure of the Type VI Secretion System Contractile Sheath [PDF]
Cell, 2015 Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver effectors into a target cell. Here, we present an atomic-resolution structure of a native contracted Vibrio cholerae sheath determined by cryo-electron microscopy. The sheath subunits, composed of tightly interacting proteins VipA and VipB, assemble into a
Kudryashev, Mikhail +9 more
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Type VI secretion: a beginner's guide [PDF]
, 2008 Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Bailey, Christopher +7 more
core +1 more source
Tagging the type VI secretion system [PDF]
Nature Microbiology, 2018 Bacteria use multiple mechanisms to secrete proteins across their envelope and gain access to resources in their niche. The type VI secretion system (T6SS) specializes in injecting toxic protein effectors by direct contact, killing the target eukaryotic or bacterial cells1.
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Adaptor Proteins of Type VI Secretion System Effectors [PDF]
Trends in Microbiology, 2017 Bacteria use the type VI secretion system (T6SS) to kill neighboring cells. One key feature of the T6SS is the secretion of diverse effectors. Here, we discuss six publications that describe three superfamilies of T6SS proteins, each dedicated to mediate the secretion of cognate effectors.
Unterweger, D, Kostiuk, B, Pukatzki, S
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Characterization of Type VI secretion system in Edwardsiella ictaluri
PLOS ONE, 2023 Edwardsiella ictaluri is a Gram-negative facultative intracellular fish pathogen causing enteric septicemia of catfish (ESC). While various secretion systems contribute to E. ictaluri virulence, the Type VI secretion system (T6SS) remains poorly understood. In this study, we constructed 13 E.
Safak Kalindamar +5 more
openaire +3 more sources
Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa. [PDF]
PLoS ONE, 2013 Three Type VI Secretion System (T6SS) loci called H1- to H3-T6SS coexist in Pseudomonas aeruginosa. H1-T6SS targets prokaryotic cells whereas H2-T6SS mediates interactions with both eukaryotic and prokaryotic host cells.
Thibault G Sana +4 more
doaj +1 more source
Established microbial colonies can survive type VI secretion assault [PDF]
, 2015 Type VI secretion (T6S) is a cell-to-cell injection system that can be used as a microbial weapon. T6S kills vulnerable cells, and is present in close to 25% of sequenced Gram-negative bacteria.
Ned S Wingreen +12 more
core +2 more sources
Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system
Nature Communications, 2020 Bacterial Rhs proteins with toxic domains are often secreted by type VI secretion systems. Here, the authors show that one of these proteins self-cleaves into three fragments, with the Rhs core and the N-terminal domain facilitating secretion and ...
Tong-Tong Pei +11 more
doaj +1 more source
Prediction of type III secretion signals in genomes of gram-negative bacteria [PDF]
, 2009 Background: Pathogenic bacteria infecting both animals as well as plants use various mechanisms to transport virulence factors across their cell membranes and channel these proteins into the infected host cell.
Löwer, Martin +5 more
core +2 more sources
Analysis of the outer membrane proteome and secretome of Bacteroides fragilis reveals a multiplicity of secretion mechanisms. [PDF]
PLoS ONE, 2015 Bacteroides fragilis is a widely distributed member of the human gut microbiome and an opportunistic pathogen. Cell surface molecules produced by this organism likely play important roles in colonization, communication with other microbes, and ...
Marlena M Wilson +2 more
doaj +1 more source