Results 1 to 10 of about 2,607 (202)

Type XVII collagen coordinates proliferation in the interfollicular epidermis [PDF]

eLife, 2017
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa.
Mika Watanabe, Ken Natsuga, Wataru Nishie, Yasuaki Kobayashi, Giacomo Donati, Shotaro Suzuki, Yu Fujimura, Tadasuke Tsukiyama, Hideyuki Ujiie, Satoru Shinkuma, Hideki Nakamura, Masamoto Murakami, Michitaka Ozaki, Masaharu Nagayama, Fiona M Watt, Hiroshi Shimizu   +15 more
doaj   +7 more sources

Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer [PDF]

BMC Cancer, 2023
Background Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in maintaining tissue structure and ...
Marina Crespo-Bravo, Jeppe Thorlacius-Ussing, Neel I. Nissen, Rasmus S. Pedersen, Mogens K. Boisen, Maria Liljefors, Astrid Z. Johansen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen   +9 more
doaj   +6 more sources

Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models [PDF]

Frontiers in Immunology, 2019
Bullous pemphigoid (BP), the most common autoimmune blistering disease, is induced by autoantibodies to type XVII collagen (COL17). Previous studies demonstrated that COL17 harbors several epitopes targeted by autoreactive T and B cells and that the ...
Hideyuki Ujiie, Norihiro Yoshimoto, Ken Natsuga, Ken Muramatsu, Hiroaki Iwata, Wataru Nishie, Hiroshi Shimizu   +6 more
doaj   +4 more sources

Anti-idiotypic Antibodies against BP-IgG Prevent Type XVII Collagen Depletion [PDF]

Frontiers in Immunology, 2017
Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However,
Mayumi Kamaguchi, Mayumi Kamaguchi, Hiroaki Iwata, Yuiko Mori, Ellen Toyonaga, Hideyuki Ujiie, Yoshimasa Kitagawa, Hiroshi Shimizu   +7 more
doaj   +6 more sources

Identification of a human type XVII collagen fragment with high capacity for maintaining skin health [PDF]

Synthetic and Systems Biotechnology
Collagen XVII (COL17) is a transmembrane protein that mediates skin homeostasis. Due to expression of full length collagen was hard to achieve in microorganisms, arising the needs for selection of collagen fragments with desired functions for microbial ...
Xinglong Wang, Shuyao Yu, Ruoxi Sun, Kangjie Xu, Kun Wang, Ruiyan Wang, Junli Zhang, Wenwen Tao, Shangyang Yu, Kai Linghu, Xinyi Zhao, Jingwen Zhou   +11 more
doaj   +3 more sources

Physicochemical characterization, cellular bioactivity, and biosafety evaluation of type A recombinant humanized collagen type XVII

Journal of Applied Biomaterials & Functional Materials
Collagen type XVII is a unique transmembrane protein that plays a crucial role in anchoring epithelial cells to the underlying basement membrane. However, the low natural abundance of collagen type XVII in the human body poses significant challenges for ...
Nana Han, Xingxing Gao, Lu Song, Jian Wang, Ling Li, Kaixuan Guo, Huan Hu, Jing Wang, Bo Fan, Yun Zhu, Xia Yang   +10 more
doaj   +3 more sources

Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders [PDF]

Frontiers in Immunology, 2022
Pemphigoid diseases (PD) are autoimmune skin blistering diseases characterized by autoantibodies directed against proteins of the cutaneous basement membrane zone (BMZ).
Bianca Opelka, Enno Schmidt, Enno Schmidt, Stephanie Goletz   +3 more
doaj   +2 more sources

Pterostilbene and Its Glucoside Induce Type XVII Collagen Expression [PDF]

Natural Product Communications, 2017
The glycosylation of pterostilbene by cultured plant cells of Phytolacca americana gave pterostilbene 4′- O-β-D-glucoside. Both pterostilbene and its 4- O-β-D-glucoside induced type XVII collagen expression in the EpiDermFT EFT-400 human skin cell model.
Hiroki, Hamada, Kei, Shimoda, Yoshiyuki, Horio, Tsubasa, Onoa, Ryusuke, Hosoda, Noriyuki, Nakayama, Koichi, Uranod   +6 more
openaire   +3 more sources

Cloning of Hamster Type XVII Collagen cDNA, and Pathogenesis of Anti-Type XVII Collagen Antibody and Complement in Hamster Bullous Pemphigoid [PDF]

Journal of Investigative Dermatology, 2002
Bullous pemphigoid is an inflammatory subepidermal blistering skin disease associated with an IgG autoimmune response to the type XVII collagen. The immunopathologic features of bullous pemphigoid can be reproduced in mice by the passive transfer of anti-type XVII collagen antibodies.
Yamamoto, Katsushi, Inoue, Naokazu, Masuda, Riako, Fujimori, Akira, Saito, Toshiyuki, Imajoh-Ohmi, Shinobu, Shinkai, Hiroshi, Sakiyama, Hisako   +7 more
openaire   +3 more sources

Targeting of the hNC16A collagen domain to dendritic cells induces tolerance to human type XVII collagen [PDF]

Experimental Dermatology, 2012
Abstract:  Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC‐hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII collagen in a skin ...
Monika, Ettinger, Iris K, Gratz, Christina, Gruber, Cornelia, Hauser-Kronberger, Theron S, Johnson, Karsten, Mahnke, Josef, Thalhamer, Helmut, Hintner, Doris, Peckl-Schmid, Johann W, Bauer   +9 more
openaire   +3 more sources