Results 171 to 180 of about 7,163,146 (192)

Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways. [PDF]

Mol Med Rep
Wang J, Lin S, Wei Y, Ye Z.
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Abstract 1340: Type XVII collagen biology is central in the fibro-immune axis of tumor fibrosis: serological assessment of type XVII collagen

Cancer Research, 2023
Abstract Background: Collagens are the main components of the desmoplastic reaction of the tumors stroma, resulting in tumors fibrosis. Immuno-oncology (IO) is a central part of treating and understanding solid tumor patients. Alterations in the extracellular matrix (ECM) are known to contribute to tumor progression and metastasis ...
Marina Crespo-Bravo, Rasmus S. Pedersen, Jeppe Thorlacius-Ussing, Nicholas Willumsen, Morten A. Karsdal   +4 more
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Severe tracheal involvement in type XVII collagen junctional epidermolysis bullosa

British Journal of Dermatology, 2023
In COLXVII-junctional epidermolysis bullosa, mucosal involvement remains inconsistent and is limited to the oral cavity and the oesophagus. We documented the observation of a patient presenting with tracheal damage.
Alizée Bozonnat, Laura Polivka, Stéphanie Leclerc-Mercier, Romain Luscan, Fabienne Charbit-Henrion, Christine Bodemer, Alexandre Lapillonne, Smail Hadj-Rabia   +7 more
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Targeting of the hNC16A collagen domain to dendritic cells induces tolerance to human type XVII collagen

Experimental Dermatology, 2012
Abstract:  Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC‐hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII collagen in a skin ...
Monika, Ettinger, Iris K, Gratz, Christina, Gruber, Cornelia, Hauser-Kronberger, Theron S, Johnson, Karsten, Mahnke, Josef, Thalhamer, Helmut, Hintner, Doris, Peckl-Schmid, Johann W, Bauer   +9 more
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Type XVII collagen and collagen-like molecules: related by more than a common motif

Seminars in Cell & Developmental Biology, 1996
Abstract Historically, collagens have been defined as extracellular matrix structural proteins whose sequence is characterized by many repeats of a three amino acid unit, GLY-X-Y. However, the latter motif has been identified in certain domains of a number of other proteins including the C1q subunit of complement, the collectins, the asymmetric form ...
Susan B. Hopkinson, Jonathan C.R. Jones
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Production of the entire extracellular domain of BP180 (type XVII collagen) by baculovirus expression

Journal of Dermatological Science, 2000
Bullous pemphigoid (BP) is an acquired autoimmune skin disease, and its target antigens are a 230 kDa plaque protein (BP230) and a 180 kDa transmembrane protein with interrupted collagenous domains (BP180, type XVII collagen), which localize at the hemidesmosome.
Y, Hata, Y, Fujii, K, Tsunoda, M, Amagai
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Discovery and Functional Characterization of a Recombinant Fragment of Human Collagen Type XVII

Journal of Agricultural and Food Chemistry
COL17A1 is predominantly expressed in skin epithelial cells and primarily localized within hemidesmosomes. It plays an essential role in epidermal-dermal attachment. Consequently, a recombinant human-like COL17A1 protein (rhCOL17) with low molecular weight and high biocompatibility presents a promising and competitive biomaterial. The aim of this study
Lianhua Piao, Jiajia Li, Xiaojing Li, Yangyang Su, Xiaofeng Yuan, Shan Chang, Xinyi Cheng, Shengwei Fu, Ren Kong   +8 more
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Pigmentation and melanocyte supply to the epidermis depend on type XVII collagen

Experimental Dermatology, 2014
Genetic deficiency of type XVII collagen (C17), laminin-332 or type VII collagen causes epidermolysis bullosa (EB). Spontaneous correction of the deficiency, also known as revertant mosaicism, is caused by a second somatic mutation that restores protein expression resulting in clinically healthy (revertant) patches surrounded by fragile (mutant) skin ...
Gostynski, Antoni, Pasmooij, Anna M. G., Del Rio, Marcela, Diercks, Gilles F., Pas, Hendrikus, Jonkman, Marcellinus   +5 more
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Two New Collagen Subgroups: Membrane-associated Collagens and Types XV and XVIII

1995
Publisher Summary This chapter discusses the two new subgroups among the large collagen gene family, the membrane-associated collagens, types XIII and XVII, and the subgroup formed, by collagen types XV and XVIII. Variant transcripts of collagens are discussed, as this phenomenon is pertinent for the members of both the new subgroups.
T, Pihlajaniemi, M, Rehn
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Generation and Characterization of Monoclonal Antibodies Against the Intracellular Domain of Hemidesmosomal Type XVII Collagen

Hybridoma, 2006
Type XVII collagen, also referred to as bullous pemphigoid antigen 2 (BPAG2) or bullous pemphigoid antigen 180 (BP180), is a transmembrane protein of the hemidesmosomal complexes of keratinocytes. Type XVII collagen has an unusual type II orientation with its N-terminus intracellularly located and with a large extracellular domain that spans lamina ...
Florina, Olaru, Sidonia, Mihai, Ioan, Petrescu, Detlef, Zillikens, Cassian, Sitaru   +4 more
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