Results 41 to 50 of about 2,607 (202)
The Diagnosis and Blistering Mechanisms of Mucous Membrane Pemphigoid
Frontiers in Immunology, 2019 Mucous membrane pemphigoid (MMP) is a mucous membrane-dominated autoimmune subepithelial blistering disease that is caused by autoantibodies against various autoantigens in basement membrane zone (BMZ) proteins, including collagen XVII (COL17 ...
Mayumi Kamaguchi +2 more
doaj +1 more source
Type XVII collagen interacts with the aPKC‐PAR complex and maintains epidermal cell polarity [PDF]
Experimental Dermatology, 2020 AbstractType XVII collagen (COL17) is a transmembrane protein expressed in the basal epidermis. COL17 serves as a niche for epidermal stem cells, and although its reduction has been implicated in altering cell polarity and ageing of the epidermis, it is unknown how COL17 affects epidermal cell polarity.
Mika Watanabe +9 more
openaire +3 more sources
The cytokine milieu of bullous pemphigoid: Current and novel therapeutic targets
Frontiers in Medicine, 2023 Bullous pemphigoid (BP) is the most common autoimmune bullous disease, characterized by severe pruritus and skin blistering. The loss of tolerance against Collagen XVII, also referred to as BP180, is the main pathogenic event of BP, leading to production
Roberto Maglie +6 more
doaj +1 more source
Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective
JEADV Clinical Practice, EarlyView.Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek +3 more
wiley +1 more source
COL17A1 editing via homology-directed repair in junctional epidermolysis bullosa
Frontiers in Medicine, 2022 BackgroundEpidermolysis bullosa (EB), a severe genetic disorder characterized by blister formation in skin, is caused by mutations in genes encoding dermal-epidermal junction proteins that function to hold the skin layers together.
Igor Petković +14 more
doaj +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background and Objectives Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the Western world. While remission is achieved in the majority of BP patients by long‐term use of corticosteroids with or without immunomodulants/immunosuppressants, national and international guidelines recommend adjuvant immunoadsorption (IA)
Maike M. Holtsche +7 more
wiley +1 more source
Similar Ehlers–Danlos Syndrome Profiles Produced by Variants in Multiple Collagen Genes
DNABackground: Despite increased attention to double-jointedness or joint hypermobility as seen in connective tissue dysplasias like Ehlers–Danlos syndrome, improved clinical DNA correlations are needed to reduce decadal delays in diagnosis.
Sahil S. Tonk, Golder N. Wilson
doaj +1 more source
Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice. [PDF]
PLoS ONE, 2012 Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and adult ...
Tracy L Adair-Kirk +9 more
doaj +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source