Results 181 to 190 of about 1,001,494 (307)

<i>BCR::ABL1</i> Mutational Profiling in US Patients With Chronic-phase Chronic Myeloid Leukemia on Tyrosine Kinase Inhibitors. [PDF]

Cancer Diagn Progn
Haddad FG, Jabbour EJ, Gutkin SW, Pathak AK, Zhai Y, Kantarjian HM.   +5 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins. [PDF]

PLoS Pathog
Brito C, Mesquita FS, Pereira JM, Osório DS, Billington N, Lima RR, Vale-Costa S, Sellers JR, Cabanes D, Carvalho AX, Sousa S.   +10 more
europepmc   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Protection Against Cellular Toxicity from Rotenone Treatment by the Neuroprotective, Novel Multifunctional Antiparkinsonian Drug D-512. [PDF]

J Pers Med
Ravipati P, Xu L, Yedlapudi D, Dutta AK.
europepmc   +1 more source

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

Cell, 1998
Weiguo Zhang, J. Sloan-Lancaster, J. Kitchen, R. Trible, L. Samelson   +4 more
semanticscholar   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Electrochemical determination of tyrosine in the presence of uric acid at a carbon paste electrode modified with multi-walled carbon nanotubes enhanced by sodium dodecyl sulfate

Open Chemistry, 2012
Ghoreishi Sayed, Behpour Mohsen, Delshad Mona, Khoobi Asma   +3 more
doaj   +1 more source

Functionalized graphene quantum dots based non-enzymatic sensor for selective tyrosine detection. [PDF]

RSC Adv
Sriram P, Nesakumar N, Rayappan JBB.
europepmc   +1 more source

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan, Le Tang, Tongji Xie, Mengwei Yang, Lin Li, Sheng Yang, Puyuan Xing, Xiaohong Han, Yuankai Shi   +8 more
wiley   +1 more source