Results 221 to 230 of about 1,001,494 (307)

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases. [PDF]

Angew Chem Int Ed Engl
Poulou E, Ruwolt M, Stieger CE, Kemnitz-Hassanin K, Hackenberger CPR.   +4 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice. [PDF]

PLoS One
Bannikova AE, Pronina TS, Troshev DV, Bogdanov VV, Kolacheva AA, Pavlova EN, Blokhin VE, Kalashnikova VI, Ugrumov MV.   +8 more
europepmc   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, EarlyView.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Peas in Rouge: Tyrosine Supplementation Enhances RUBY Reporter Visibility in <i>Pisum sativum</i>. [PDF]

Plants (Basel)
Simonova V, Potsenkovskaia E, Kozlov N, Vanina A, Efremova E, Smirnov K, Artemiuk A, Kiseleva A, Brynchikova A, Konstantinov Z, Tvorogova V.   +10 more
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

UMI-77 Ameliorates Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy by Modulating the Brain-Gut Axis. [PDF]

Brain Behav
Ke Y, Dong C, Liu C, Ni M, Chen Y, Zhang Y, Wang Y, Xu Y, Chen G.   +8 more
europepmc   +1 more source

Catalytic relevance of a quinol anion in biological energy conversion by respiratory complex I. [PDF]

Chem Sci
Zdorevskyi O, Laukkanen J, Sharma V.
europepmc   +1 more source