Results 71 to 80 of about 674,878 (317)

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Molecules
An environmentally friendly and sustainable approach was adopted to produce a molecularly imprinted polymer (MIP) via electropolymerization, with remarkable electrochemical sensing properties, tested in tyrosine (tyr) detection.
Francesco Gagliani, Tiziano Di Giulio, Sara Grecchi, Tiziana Benincori, Serena Arnaboldi, Cosimino Malitesta, Elisabetta Mazzotta   +6 more
doaj   +1 more source

Serum tryptophan, kynurenine, phenylalanine, tyrosine and neopterin concentrations in 100 healthy blood donors

Pteridines, 2015
Formation of neopterin, a biomarker of the activated human immune system, is linked with tryptophan (TRP) and phenylalanine (PHE) metabolism. To obtain normal values, in this study, serum concentrations of neopterin as well as of TRP, PHE and their ...
Geisler Simon, Mayersbach Peter, Becker Kathrin, Schennach Harald, Fuchs Dietmar, Gostner Johanna M.   +5 more
doaj   +1 more source

Probing Functional Tyrosines

Chemistry & Biology, 2013
Reactivity probes are small molecules that contain a reactive electrophile and a purification handle, and are used to identify hyperreactive amino acid residues within a whole proteome. In this issue of Chemistry & Biology, Gu et al. use sulfonyl fluoride derivatives for the identification of functional tyrosine residues in different classes of ...
openaire   +3 more sources

Peptide Tyrosine-Tyrosine (PYY) — An Evolutionary Perspective [PDF]

American Zoologist, 1995
The hormone peptide tyrosine-tyrosine (PYY), first isolated from pig intestine, islocalized to endocrine cells in the lower bowel and exercises a predominantly inhibitory actionon gastro-intestinal function. Mammalian tissues also produce the homologous peptides neuropeptide Y, localized to central and peripheral neurons, and pancreatic polypeptide ...
openaire   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Association of phenylalanine and tyrosine metabolism with mortality and response to nutritional support among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT

Frontiers in Nutrition
BackgroundElevated phenylalanine serum level is a surrogate marker of whole-body proteolysis and has been associated with increased mortality in critically ill patients.
Lena C. Buchmueller, Lena C. Buchmueller, Carla Wunderle, Rahel Laager, Rahel Laager, Rahel Laager, Luca Bernasconi, Peter J. Neyer, Pascal Tribolet, Pascal Tribolet, Pascal Tribolet, Zeno Stanga, Beat Mueller, Beat Mueller, Philipp Schuetz, Philipp Schuetz   +15 more
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC‐QTOF‐MS

JIMD Reports, 2019
Background The homogentisic acid‐lowering therapy nitisinone is being evaluated for the treatment of alkaptonuria (AKU) at the National Centre for AKU. Beyond hypertyrosinemia, the wider metabolic consequences of its use are largely unknown.
Andrew S. Davison, Brendan P. Norman, Gordon A. Ross, Andrew T. Hughes, Milad Khedr, Anna M. Milan, James A. Gallagher, Lakshminarayan R. Ranganath   +7 more
doaj   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source