Results 81 to 90 of about 681,049 (265)

Preoperative Tyrosine Levels as Predictive Biomarkers for Excessive Fat-Free Mass Loss Following Laparoscopic Sleeve Gastrectomy in Patients with Morbid Obesity

Metabolites
Background/Objectives: Fat-free mass (FFM) loss after metabolic and bariatric surgery (MBS) is associated with adverse long-term outcomes, including osteoporosis.
Inyoung Lee, Eunhye Seo, Yeongkeun Kwon, Chang Min Lee, Nam Hoon Kim, Jong-Han Kim, Sung Il Choi, Sungsoo Park   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Amino acid supplementation in mitochondrial aminoacyl-tRNA synthetase defects: two case reports of tyrosine supplementation in YARS2-associated disease and a review of the literature

Frontiers in Pediatrics
BackgroundMitochondrial diseases (MDs) caused by pathogenic variants in aminoacyl-tRNA synthetase (ARS) genes, either cytosolic (ARS1) or mitochondrial (ARS2), are rare and clinically diverse.
Giulia Ferrera, Giulia Ferrera, Giorgia Segre, Eleonora Lamantea, Daniele Ghezzi, Daniele Ghezzi, Marta Rivelli, Anna Ardissone   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Application of a risk score model based on tyrosine-related genes in the prognosis and treatment of patients with lung adenocarcinoma

Frontiers in Immunology
BackgroundTyrosine is associated with alterations in the tricarboxylic acid cycle in lung cancer, and exploring tyrosine-related genes (TRGs) has the potential to contribute to the construction of new sensitive prognostic biomarkers for patients with ...
Huan Wang, Yuebei Li, Ke Liu, Xinyuan Fan   +3 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Serum tyrosine increases all-cause mortality in an older population

Frontiers in Endocrinology
PurposeAmino acids play crucial roles in metabolic and cardiovascular diseases, especially branched-chain and aromatic amino acids, but their association with mortality remains understudied and inconclusive.
Yuhong Dai, Yong Zhang, Yue Zhang, Haoran Zheng, Ling Xiang, Liang Cheng, Xiaoqing Wang, Jie Zhang, Hairong Hao, De Huai, Wen Hu   +10 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Hypozincemia Is Associated With Increased Tyrosine Levels, Low Handgrip Strength, Increased Incidence of HCC, and Liver Disease Progression—A Cross‐Sectional Study

JGH Open
Background Serum zinc levels decrease in chronic liver disease (CLD), but their effects on liver reserve function, tyrosine, skeletal muscle mass, handgrip strength (HGS), and hepatocellular carcinoma (HCC) development remain poorly understood. Methods A
Tomoo Kobayashi, Jun Inoue, Yu Tanaka, Mitsuru Yamakawa, Makoto Kurihara, Tomoko Handa, Yutaka Kondo, Akihiro Saitou, Manabu Shiraki, Yasuhiro Kojima, Motoki Ohyauchi, Atsushi Masamune   +11 more
doaj   +1 more source

HS-Associated Pasteurella multocida Infection Disrupts Gut Microbiota and Metabolism in Mice

Microorganisms
Pasteurella multocida serotype B:2 is a primary agent of hemorrhagic septicemia (HS) in livestock, and the strain NQ01 isolated from yaks highlights its cross-species impact.
Kewei Li, Chao Jin, Haofang Yuan, Muhammad Farhan Rahim, Xire Luosong, Tianwu An, Jiakui Li   +6 more
doaj   +1 more source