Advanced Science, EarlyView.A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu +10 more
wiley +1 more source
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). [PDF]
, 1988 Jamey D. Marth +7 more
openalex +1 more source
Advanced Science, EarlyView.PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal +23 more
wiley +1 more source
A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis. [PDF]
, 1987 Annemarie Honegger +7 more
openalex +1 more source
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR‐Altered Bladder Cancer
Advanced Science, EarlyView.Coatomer protein complex subunit α facilitates the transport of the cargo protein LRPPRC across the Golgi complex and enhances its stability, thereby increasing LRPPRC expression; LRPPRC promotes the stability of ID3 mRNA in an m6A‐dependent manner, thereby decreasing the transcriptional activity of p16 and p21, which leads to increased erdafitinib ...
Huayuan Zhao +10 more
wiley +1 more source
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. [PDF]
, 1986 Kathleen L. Gould +3 more
openalex +1 more source
Advanced Science, EarlyView.Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li +12 more
wiley +1 more source
Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Advanced Science, EarlyView.Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai +5 more
wiley +1 more source
Editorial: Targeting Bruton Tyrosine Kinase
Frontiers in Cell and Developmental Biology, 2022 Cornelia Brunner +4 more
doaj +1 more source
Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl. [PDF]
, 1989 John L. Cleveland +4 more
openalex +1 more source