Results 191 to 200 of about 438,950 (335)

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

Covalent Bruton tyrosine kinase inhibitors across generations: A focus on zanubrutinib. [PDF]

J Cell Mol Med
Broccoli A, Del Re M, Danesi R, Zinzani PL.   +3 more
europepmc   +1 more source

Substrate specificities of tyrosine-specific protein kinases toward cytoskeletal proteins in vitro.

, 1986
Tetsu Akiyama, Takashi Kadowaki, Eisuke Nishida, Tetsuya Kadooka, Hiroshi Ogawara, Yuko Fukami, Hikoichi Sakai, Fumimaro Takaku, Masato Kasuga   +8 more
openalex   +1 more source

Tyrosine Kinases in Cancer.

Biomarker insights, 2015
Blau, Olga, Afanasyev, Boris, Blau, Igor Wolfgang   +2 more
openaire   +2 more sources

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense

BioFactors, Volume 48, Issue 6, Page 1217-1225, November/December 2022., 2022
Abstract Platelet‐activating factor (PAF, 1‐alkyl‐2‐acetyl‐sn‐glycero‐3‐phosphorylcholine) was discovered when the mechanisms involved in the deposition of immune complex in tissues were being scrutinized in the experimental model of rabbit serum sickness.
Mariano Sánchez Crespo, Olimpio Montero, Nieves Fernandez   +2 more
wiley   +1 more source

Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy. [PDF]

Mediators Inflamm
Tang KT, Chen YS, Chen TT, Chao YH, Kung SP, Chen DY, Lin CC.   +6 more
europepmc   +1 more source

Hypothalamus Regulates Anabolic Metabolism of Articular Cartilage Superficial Chondrocytes through PGE2 Skeletal Interoception

Advanced Science, EarlyView.
Hypothalamus sympathetic norepinephrine inhibits regeneration of articular cartilage. Mechanical loading on bone during animal activity elevates PGE2 skeletal interoception to promote an anabolic renewal of the superficial membrane by downregulation of norepinephrine for articular cartilage proper thickness and integrity.
Ziyi Wang, Xuequan Han, Jiawen Xu, Weixin Zhang, Kalp Patel, Jinjian Zheng, Mei Wan, Junying Zheng, Xu Cao   +8 more
wiley   +1 more source

Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor.

, 1982
Bo Ek, Carl‐Henrik Heldin
openalex   +1 more source

Functional Heterogeneity of Proto-Oncogene Tyrosine Kinases: the C Terminus of the Human Epidermal Growth Factor Receptor Facilitates Cell Proliferation [PDF]

, 1989
Thierry Velu, William C. Vass, Douglas R. Lowy, Laura Beguinot   +3 more
openalex   +1 more source