IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex
Advanced Science, EarlyView.This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv +6 more
wiley +1 more source
Tyrosine kinase inhibitors modulate the expression of peroxiredoxins 1 and 2 in chronic myeloid leukemia cells. [PDF]
Leuk Res RepKazama H, Wang YH, Tanaka J.
europepmc +1 more source
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source
Current management of neurotrophic receptor tyrosine kinase fusion-positive sarcoma: an updated review. [PDF]
Jpn J Clin OncolKubota Y +6 more
europepmc +1 more source
Kidney injury: the spleno-renal connection and splenic tyrosine kinase. [PDF]
J NephrolAlmasry Y +5 more
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Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. [PDF]
, 1994 Richard Binari, Norbert Perrimon
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A Fast Method to Monitor Tyrosine Kinase Inhibitor Mechanisms. [PDF]
J Med ChemFernández A +3 more
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Identification and characterization of cellular targets for tyrosine protein kinases.
, 1983 Jonathan A. Cooper, Tony Hunter
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Bosutinib-Induced Pleural Effusion-Class Effect and Cross-Intolerance to All Tyrosine Kinase Inhibitors. [PDF]
Hematol RepVojjala N +7 more
europepmc +1 more source