Results 321 to 330 of about 787,124 (352)

PROTEIN-TYROSINE KINASES

Annual Review of Biochemistry, 1985
Tony Hunter, Jonathan A. Cooper
openaire   +3 more sources

The Viral Tyrosine Protein Kinases

1986
The acutely transforming retroviruses have revealed the existence of more than twenty different genes with oncogenic potential. Seven of these — src, abl, yes, erbB, fps (fes), fgr, fms, and ros — encode proteins with intrinsic tyrosine protein kinase activity.
openaire   +3 more sources

Tyrosine Kinase Signaling at Fertilization

Biochemical and Biophysical Research Communications, 1997
The unfertilized egg is a highly differentiated cell that retains unlimited developmental potential. The execution of that potential requires signal transduction pathways that release the egg from its quiescent metabolic state, direct the union of the maternal and paternal genome, and initiate a developmental program that will guide embryogenesis.
openaire   +3 more sources

Trends in kinase drug discovery: targets, indications and inhibitor design

Nature Reviews Drug Discovery, 2021
Helgi B Schiöth, Misty M Attwood, Stefan Knapp   +2 more
exaly  

Tyrosine Kinase Inhibitors

2007
The extraordinary success of imatinib for the treatment of chronic myeloid leukemia (CML), gastrointestinal stromal tumors and subgroups of patients with hypereosinophilic syndrome and chronic myelomonocytic leukemia has greatly stimulated the development of small molecule inhibitors for targeted therapy of malignant diseases.
openaire   +2 more sources

Treatment of renal cell carcinoma: Current status and future directions

Ca-A Cancer Journal for Clinicians, 2017
Pedro Barata, Brian I Rini
exaly  

Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, 2021
Darren Cross, Pasi A Jänne, Philip Cohen   +2 more
exaly  

Kinase inhibition in autoimmunity and inflammation

Nature Reviews Drug Discovery, 2021
Ali A Zarrin, Bruno Hochhegger, Katherine Bao   +2 more
exaly  

Lung cancer: New biological insights and recent therapeutic advances

Ca-A Cancer Journal for Clinicians, 2011
Suresh S Ramalingam, Taofeek K Owonikoko, Fadlo R Khuri   +2 more
exaly  

Syk Tyrosine Kinase

2008
Susette C. Mueller, Peter J. Coopman
openaire   +1 more source