Results 31 to 40 of about 1,906,742 (351)

The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm [PDF]

, 2016
Sperm capacitation is required for fertilization. At the molecular level, this process is associated with fast activation of protein kinase A. Downstream of this event, capacitating conditions lead to an increase in tyrosine phosphorylation. The identity
Alvau, Antonio, Battistone, Maria Agustina, Cuasnicu, Patricia Sara, Da Ros, Vanina Gabriela, Darszon, Alberto, De la Vega Beltran, José Luis, Gervasi, Maria Gracia, Greer, Peter, Krapf, Diego, Navarrete, Felipe A., Salicioni, Ana María, Sánchez Cárdenas, Claudia, Visconti, Pablo E., Xu, Xinran   +13 more
core   +1 more source

Advances in studies of tyrosine kinase inhibitors and their acquired resistance

Molecular Cancer, 2018
Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell signal transduction, which catalyzes the transfer of ATP-γ-phosphate to the tyrosine residues of the substrate protein, making it phosphorylation, regulating cell ...
Qinlian Jiao, Lei Bi, Yidan Ren, Shuliang Song, Qin Wang, Yun-shan Wang   +5 more
semanticscholar   +1 more source

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase [PDF]

Molecular and Cellular Biology, 1995
Bruton's tyrosine kinase (Btk) is tyrosine phosphorylated and enzymatically activated following ligation of the B-cell antigen receptor. These events are temporally regulated, and Btk activation follows that of various members of the Src family of protein tyrosine kinases, thus raising the possibility that Src kinases participate in the Btk activation ...
S, Mahajan, J, Fargnoli, A L, Burkhardt, S A, Kut, S J, Saouaf, J B, Bolen   +5 more
openaire   +2 more sources

A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. [PDF]

, 2016
The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers.
Babicky, M, Chakedis, J, French, R, Holman, P, Howard, H, Jaquish, D, Lam, R, Lowy, AM, Miyamoto, J, Mose, E, Walterscheid, Z   +10 more
core   +2 more sources

Receptor Tyrosine Kinase-Targeted Cancer Therapy

International Journal of Molecular Sciences, 2018
In the past two decades, several molecular targeted inhibitors have been developed and evaluated clinically to improve the survival of patients with cancer. Molecular targeted inhibitors inhibit the activities of pathogenic tyrosine kinases. Particularly,
T. Yamaoka, S. Kusumoto, Koichi Ando, M. Ohba, T. Ohmori   +4 more
semanticscholar   +1 more source

Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria [PDF]

, 1985
A series of plasmids containing different segments of the v-abl oncogene have been constructed to express different portions of the v- abl protein in bacteria.
Baltimore, David, Wang, Jean Y. J.
core  

Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors

Journal of Thoracic Oncology, 2018
Introduction: We analyzed a large set of EGFR‐mutated (EGFR+) NSCLC to identify and characterize cases with co‐occurring kinase fusions as potential resistance mechanisms to EGFR tyrosine kinase inhibitors (TKIs).
A. Schrock, V. Zhu, W. Hsieh, R. Madison, B. Creelan, J. Silberberg, D. Costin, A. Bharne, Ioana R. Bonta, Thangavijayan Bosemani, P. Nikolinakos, J. Ross, V. Miller, Siraj M. Ali, S. Klempner, S. Ou   +15 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source