Advanced Science, EarlyView.A therapeutic strategy is proposed for periodontitis using extracellular vesicles derived from EPO‐stimulated macrophages (EPO‐EVs). This schema demonstrates how EPO‐EVs enhance the osteogenic activity of mBMSCs in an inflammatory environment by inhibiting EGFR.
Shuchen Liu +10 more
wiley +1 more source
Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization
Advanced Science, EarlyView.This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim +12 more
wiley +1 more source
Covalent Bruton tyrosine kinase inhibitors across generations: A focus on zanubrutinib. [PDF]
J Cell Mol MedBroccoli A +3 more
europepmc +1 more source
Genetic Mapping and Functional Studies of a Natural Inhibitor of the Insulin Receptor Tyrosine Kinase: The Mouse Ortholog of Human α2‐HS Glycoprotein [PDF]
, 2000 Vivian J. Cintrón +6 more
openalex +1 more source
Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6
Advanced Science, EarlyView.Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee +3 more
wiley +1 more source
Comparative efficacy and safety of transarterial chemoembolization combined with tyrosine kinase inhibitors and immune checkpoint inhibitors versus tyrosine kinase inhibitors and immune checkpoint inhibitors alone in advanced hepatocellular carcinoma: a systematic review and meta-analysis. [PDF]
World J Surg OncolTian H, Wan C.
europepmc +1 more source
Advanced Science, EarlyView.How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu +13 more
wiley +1 more source
Clastogenic effects of two tyrosine kinase inhibitors, Tyrphostin 23 and Tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic Chinese hamster cell line (CHE) [PDF]
, 2000 Loredana Bassi
openalex +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Tyrosine kinase inhibitors modulate the expression of peroxiredoxins 1 and 2 in chronic myeloid leukemia cells. [PDF]
Leuk Res RepKazama H, Wang YH, Tanaka J.
europepmc +1 more source