Results 241 to 250 of about 871,767 (407)

The role of microglia in multiple sclerosis: implications for treatment with Bruton's tyrosine kinase inhibitors. [PDF]

Front Immunol
Vermersch P, Airas L, Berger T, Deisenhammer F, Grigoriadis N, Hartung HP, Magyari M, Popescu V, Pozzilli C, Pugliatti M, Van Wijmeersch B, Zakaria M, Oreja-Guevara C.   +12 more
europepmc   +1 more source

Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice

Advanced Science, EarlyView.
An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen, Ruiqing Hou, Zhinan Chen, Junli Lu, Si Chen, Shisheng Xiong, Jianfeng Feng, Trevor W. Robbins, Haitao Yan, Xiao Xiao   +9 more
wiley   +1 more source

Hepatitis B virus reactivation in patients with hematologic malignancies treated with Bruton tyrosine kinase inhibitors. [PDF]

Blood Res
Hur JY, Lee JH, Lee JH, Park HS, Park H, Choi Y, Choi JH, Won YW, Yoon SE, Kim WS, Kim SJ.   +10 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Genetic Mapping and Functional Studies of a Natural Inhibitor of the Insulin Receptor Tyrosine Kinase: The Mouse Ortholog of Human α₂‐HS Glycoprotein [PDF]

, 2000
Vivian J. Cintrón, Minoru S.H. Ko, Dornfeld Kenneth, Jason P Gross, Pothur R. Srinivas, Anton Scott Goustin, George Grunberger   +6 more
openalex   +1 more source

Data mining and safety analysis of FGFR tyrosine kinase inhibitors based on the FAERS database. [PDF]

Sci Rep
Li P, Wu L, Song Z.
europepmc   +1 more source

Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos

Advanced Science, EarlyView.
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang, Runbo Li, Ruijie Luo, Qiang Zhang, Zimo Zhao, Haishen Xu, Minglei Zhi, Wenjie Jiang, Meng Wang, Xinze Chen, Zhiqiang Feng, Yingjie Wang, Yuhan Yang, Pengcheng He, Hanyue Su, Tianzhi Chen, Shunxin Wang, Yixuan Yao, Jinghui Yang, Fan Zhao, Tingting Li, Haitao Wang, Xiaosheng Zhang, Jinlong Zhang, Qiuyue Liu, Shuai Gao, Yuchang Yao, Jianyong Han, Suying Cao   +28 more
wiley   +1 more source

Impact of Tyrosine Kinase Inhibitors on the Expression Pattern of Epigenetic Regulators. [PDF]

Cancers (Basel)
Tóth K, Gaál Z.
europepmc   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Clastogenic effects of two tyrosine kinase inhibitors, Tyrphostin 23 and Tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic Chinese hamster cell line (CHE) [PDF]

, 2000
Loredana Bassi
openalex   +1 more source