Results 51 to 60 of about 2,848,207 (306)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Composites Part C: Open AccessThis study successfully explored and evaluated the impact of notches modification in U, V, and square shapes on both tensile and shear strength using Arcan fixture.
Ariyana Dwiputra Nugraha +5 more
doaj +1 more source
Biomedicines, 2022 (1) Background: PTC124 (Ataluren) is an investigational drug for the treatment of nonsense mutation-mediated genetic diseases. With the exception of the TP53 tumor suppressor gene, there has been little research on cancers with nonsense mutation.
Ming-Han Wu +9 more
doaj +1 more source
A NOVEL RECTANGLE TREE FRACTAL UWB ANTENNA WITH DUAL BAND NOTCH CHARACTERISTICS
, 2016 A novel rectangle tree fractal antenna (RTFA) for ultra-wideband (UWB) application with dual band notch characteristics is proposed. The radiating path is the tree fractal structure which is formed by the superposition of a number of rectangular patches,
Zhangfang Hu +3 more
semanticscholar +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Applicability of Semi-Quantitative Evaluation of the Intercondylar Notch
Applied Sciences, 2021 The intercondylar notch (IN) can differ in morphology and size, influencing the contained ligaments. For a better understanding of the influence of the IN’s anatomy on knee pathologies, a classification of different shapes was proposed.
Lena Hirtler +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Effects of Edentulism on Mandibular Morphology: Evaluation of Panoramic Radiographs
The Scientific World Journal, 2014 Purpose. The objective of this study was to evaluate morphological changes of the mandible in edentulous and dentate subjects using panoramic radiographs. Materials and Methods. Panoramic radiographs were divided into the following three groups: Group I (
Rıdvan Okşayan +5 more
doaj +1 more source