Results 121 to 130 of about 468,322 (270)

Characterization of Strategic Deconflicting Service Impact on Very Low-Level Airspace Capacity

Drones
European airspace is poised for significant transformation as it prepares to accommodate a new class of unmanned traffic that will reshape the transport of people and goods.
Zhiqiang Liu, Jose Luis Munoz-Gamarra, Juan José Ramos Gonzalez   +2 more
doaj   +1 more source

Measuring U-space social and environmental impact

U-space will enable urban air mobility (UAM) on a wide scale, facilitating a variety of use cases (e.g., medical and emergency transport, delivery of goods, passenger transport services). Social acceptance and impact on citizens is not completely understood in this growing scenario.
Baena, Miguel, Kuljanin, Jovana, Legriffon, Ingrid, Ganic, Emir, Barrado Muxí, Cristina, Mocholí, David, Ruaud, Elise, Torre Sangrà, David de la   +7 more
openaire   +3 more sources

U-Space Contingency Management Based on Enhanced Mission Description

Aerospace
Loss of communication, low battery, or bad weather conditions (like high-speed wind) are currently managed by performing a return to launch (RTL) point maneuver. However, the execution of this procedure can pose a safety threat since it has not been considered within the mission planning process. This work proposes an advanced management of contingency
Jose L. Munoz-Gamarra, Juan J. Ramos, Zhiqiang Liu   +2 more
openaire   +4 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Regularity of weak solutions of the Navier-Stokes equations near the smooth boundary

Electronic Journal of Differential Equations, 2005
Any weak solution u of the Navier-Stokes equations in a bounded domain satisfying the Prodi-Serrin's conditions locally near the smooth boundary cannot have singular points there.
Zdenek Skalak
doaj  

Weighted composition operators on $ \alpha $-Bloch-Orlicz spaces over the unit polydisc

AIMS Mathematics
Let $ {\mathbb{U}}^{n} $ be the unit polydisc in the complex vector space $ {\mathbb C}^n $. We defined the $ \alpha $-Bloch-Orlicz space on $ {\mathbb{U}}^n $ by using Young's function and showed that its norm is equivalent with a special $ \mu $-Bloch
Fuya Hu, Chengshi Huang, Zhijie Jiang
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source