Results 91 to 100 of about 15,914 (183)

ACSVL3 depletion in U87 glioma cells affects both fatty acid and cholesterol homeostasis

The FASEB Journal, 2010
Human malignant gliomas overexpress ACSVL3, a member of the very long‐chain fatty acyl‐CoA synthetase family. Depletion of ACSVL3 in cultured human U87 glioma cells by RNA interference decreased both their malignant growth properties in vitro and their ability to produce tumors in mice ...
Paul Watkins, Elizabeth Kolar, Zhengtong Pei   +2 more
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Study on synergistic effect of Rac1 inhibitor and temozolomide in inhibiting proliferation and invasiveness of glioma cells in vitro

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Objective To investigate whether Rac1 inhibitor has a synergistic effect on temozolomide (TMZ) in inhibiting the proliferation, migration and invasiveness of glioma cells.  Methods Human glioma cell lines U87 and U251 were cultured by Rac1 inhibitor,
Xiao-yong HAN, Xi-rui WANG, Zhi-huang ZHAO, Jin-xing SHANG, Gang-feng YIN, Xue-jun YANG   +5 more
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MiR-320 inhibits the growth of glioma cells through downregulating PBX3

Biological Research, 2017
Background MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putative target gene of miR-320, has been
Cuicui Pan, Hua Gao, Ni Zheng, Qi Gao, Yuanquan Si, Yueran Zhao   +5 more
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Predictive effect of γH2AX expression on the radiosensitivity of glioma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Objective To observe the expression changes of γH2AX in high-grade glioma cell lines (U87, U251 and LN229) and to investigate the relationship between the expression of γ H2AX and the radiosensitivity of high-grade glioma cells in vitro.  Methods The
Jun-wei WANG, Chun-zhi ZHANG, Bao-lin HAN, Lei-bo WANG, Xin YAO   +4 more
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Activation of PTGS2/NF‐κB signaling pathway enhances radiation resistance of glioma

Cancer Medicine, 2019
Objective We focused on the effects of PTGS2/NF‐κB signaling pathway on the radiation resistance of glioma in the study. Methods We downloaded the microarray data from the Gene Expression Omnibus (GEO) database.
Cheng Tan, Liang Liu, Xiaoyang Liu, Ling Qi, Weiyao Wang, Guifang Zhao, Libo Wang, Yimeng Dai   +7 more
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Abstract 1234: Untargeted Lipidomics in U87-MG Glioma Cells

Journal of Biological Chemistry, 2023
Grace Chao, Ellen Kuang, Erica Forsberg, Christal Sohl   +3 more
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Promising fusion protein design to target the U87 MG glioma cell line.

Asian Pacific journal of cancer prevention : APJCP, 2012
Gliomas, with a poor clinical course, account for 30% to 40% of all intracranial tumors. Immunotherapy with monoclonal antibodies has emerged as a promising area of investigation and recently it has been shown that antibodies utilize complementarity-determining regions (CDRs) of their variable domains to bind to antigens with high affinity and ...
Chen, Jing, Lin, Yuan, Pan, Xingguo, Huang, Zhijie, Chen, Zai-xi, Zhang, Ru, You, Jian   +6 more
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Metalloproteases involved in the Temozolomide (TMZ) resistance of U87-MG glioma cells

, 2013
Glioblastoma multiforme (GBM) is the most malignant type of brain tumours bearing a grim prognosis with a median survival of 14.8 months. Despite therapeutic advances over the past decades, GBM treatment remains ineffective with temozolomide (TMZ) as a standard chemotherapeutic agent. Even using TMZ combined with surgical
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Preparation and Preclinical Evaluation of ¹⁸F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1)

Molecules
Mutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies.
Roberta Cologni, Marcus Holschbach, Daniela Schneider, Dirk Bier, Annette Schulze, Carina Stegmayr, Heike Endepols, Johannes Ermert, Felix Neumaier, Bernd Neumaier   +9 more
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Resveratrol represses YKL-40 expression in human glioma U87 cells.

Resveratrol represses YKL-40 expression in human glioma U87 cells.
Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue. Clinical studies have shown that serum YKL-40 levels are positively correlated with
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