Results 151 to 160 of about 15,914 (183)
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Comparison of metabolite profiles in U87 glioma cells and mesenchymal stem cells
Biosystems, 2011Gas chromatography-mass spectrometry (GC-MS) profiles were generated from U87 glioma cells and human mesenchymal stem cells (hMSC). 37 metabolites representing glycolysis intermediates, TCA cycle metabolites, amino acids and lipids were selected for a detailed analysis.
Juerchott, Kathrin +6 more
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CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis
Journal of Neuro-Oncology, 2019Chromobox protein homolog 3 (CBX3) is one of the heterochromatin protein 1 (HP1) family members. Among multiple cancers, it is usually overexpressed. However, the mechanism and function of CBX3 in glioma remain incompletely illustrated.The expression level of CBX3 as well as its correlation with glioma are detected through TCGA and Oncomine database ...
Shu-Peng Zhao +7 more
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Polyamidoamine-Based Nanovector for The Efficient Delivery of Methotrexate to U87 Glioma Cells
Nanomedicine, 2020The purpose of this study was to design a polyamidoamine (PAMAM)-based nanovector for the efficient delivery of methotrexate to U87 glioma cells. To this end, 0-100% acetylated PAMAM dendrimers of the fourth generation were synthesized and evaluated using drug encapsulation measurements, molecular dynamics simulations, neurotoxicity assays and neuronal
Natalia Ortiz +6 more
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AnvirzelTMregulates cell death through inhibiting GSK-3 activity in human U87 glioma cells
Neurological Research, 2020Objectives: Cardiac glycosides are used as potential anti-cancer agents due to their effects on the inhibition of proliferation and induction of apoptosis and/or autophagy in cancer cells. Herein, we aimed to study the potential signaling pathways taken role in differential cell-death properties of AnvirzelTM which is consisted of two toxic cardiac ...
Sule Terzioglu-Usak +4 more
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Tamoxifen Increases Photodynamic Therapeutic Response of U87 and U25ln Human Glioma Cells
Journal of Neuro-Oncology, 2002We tested the hypothesis that Tamoxifen (TMX), an inhibitor of protein kinase C (PKC), augments the cytotoxicity of photodynamic therapy (PDT) treatment of human (U87) and (U25ln) glioma cells. U87 and U25ln glioma cells were plated and treated with PDT using Photofrin as the sensitizer.
Feng, Jiang +7 more
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CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1
Molecular and Cellular Biochemistry, 2017Glioma is stemmed from the glial cells in the brain, which is accounted for about 45% of all intracranial tumors. The characteristic of glioma is invasive growth, as well as there is no obvious boundary between normal brain tissue and glioma tissue, so it is difficult to resect completely with worst prognosis.
Jiaying, Chen +4 more
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Cell Biochemistry and Function, 2019
Glioblastoma (GBM) is the most malignant and aggressive glioma, which has a very poor prognosis. Temozolomide (TMZ) is still a first‐line treatment, but resistance is inevitable even in MGMT‐deficient glioblastoma cells. The aims of this study were to comprehend the effect of TMZ on nucleus and the underlying mechanism of acquired TMZ resistance in ...
Jinglin Guo +13 more
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Glioblastoma (GBM) is the most malignant and aggressive glioma, which has a very poor prognosis. Temozolomide (TMZ) is still a first‐line treatment, but resistance is inevitable even in MGMT‐deficient glioblastoma cells. The aims of this study were to comprehend the effect of TMZ on nucleus and the underlying mechanism of acquired TMZ resistance in ...
Jinglin Guo +13 more
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Biochemical and Biophysical Research Communications, 2011
Phospholipase D (PLD) has been recognized as a regulator of cell proliferation and tumorigenesis, but little is known about the molecules regulating PLD expression. Thus, the identification of small molecules inhibiting PLD expression would be an important advance in PLD-mediated physiology.
Mi Hee, Park, Do Sik, Min
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Phospholipase D (PLD) has been recognized as a regulator of cell proliferation and tumorigenesis, but little is known about the molecules regulating PLD expression. Thus, the identification of small molecules inhibiting PLD expression would be an important advance in PLD-mediated physiology.
Mi Hee, Park, Do Sik, Min
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Journal of Neuro-Oncology, 2001
We have identified secreted protein acidic and rich in cysteine (SPARC) as a potential glioma invasion-promoting gene. To determine whether SPARC alters the growth, attachment, or migration of gliomas, we have used U87T2 and doxycycline-regulatable SPARC-transfected clones to examine the effects of SPARC on (1) cell growth, (2) cell cycle progression, (
S A, Rempel +4 more
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We have identified secreted protein acidic and rich in cysteine (SPARC) as a potential glioma invasion-promoting gene. To determine whether SPARC alters the growth, attachment, or migration of gliomas, we have used U87T2 and doxycycline-regulatable SPARC-transfected clones to examine the effects of SPARC on (1) cell growth, (2) cell cycle progression, (
S A, Rempel +4 more
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[Effect of RNF2 knockdown on apoptosis and radiosensitivity in glioma U87 cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2014To investigate the effect of RING finger protein 2 (RNF2) knockdown on the biological characteristics and radiosensitivity in glioma U87 cells.Plasmids containing shRNA targeting RNF2 were transfected into U87 cells. Real-time quantitative PCR (qRT-PCR) and Western blotting were respectively applied to detect the mRNA and protein level of RNF2.
Chunhui, Zhou +8 more
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