Results 61 to 70 of about 15,914 (183)

Cellular Morphometric Analysis (CellMorph)—a comprehensive imaging‐based tool for quantifying cellular phenotype heterogeneity and dynamics across biological processes

The FEBS Journal, EarlyView.
CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira, Solon Andrades da Rosa, Luiza Cherobini Pereira, Laura Boose de Mendonça, Juliete Scholl, Fabrício Figueiró, Thais Cardoso Bitencourt, Davi Piovesan Echevarria, João Luiz Aldinucci Buzzo, Jessica Boschini D'Agostin, Danieli Rosane Dallemole, Carolina Oliveira, Fernanda Simas, Fernanda Saez‐Calazans, Débora Santos‐Sousa, Guido Lenz, Eduardo C. Filippi‐Chiela   +16 more
wiley   +1 more source

Agonistic Antibodies Reveal the Function of GPR56 in Human Glioma U87-MG Cells

Biological & Pharmaceutical Bulletin, 2015
GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) and is highly expressed in parts of tumor cells. The involvement of GPR56 in tumorigenesis has been reported. We generated agonistic monoclonal antibodies against human GPR56 and analyzed the action and signaling pathway of GPR56.
Shigeyuki, Ohta, Sayaka, Sakaguchi, Yuki, Kobayashi, Norikazu, Mizuno, Kenji, Tago, Hiroshi, Itoh   +5 more
openaire   +3 more sources

Atorvastatin inhibits glioma glycolysis and immune escape by modulating the miR-125a-5p/TXLNA axis

Hereditas
Background Conventional treatments, including surgery, radiotherapy and chemotherapy, have many limitations in the prognosis of glioma patients. Atorvastatin (ATOR) has a significant inhibitory effect on glioma malignancy.
Kang Gao, Tao Zhou, YingChun Yin, XiaoJie Sun, HePing Jiang, TangYue Li   +5 more
doaj   +1 more source

Plumbagin suppresses the migration and invasion of glioma cells via downregulation of MMP-2/9 expression and inaction of PI3K/Akt signaling pathway in vitro

Journal of Pharmacological Sciences, 2017
Plumbagin is a natural naphthoquinone constituent isolated from the roots of medicinal plant Plumbago zeylanica L., and has demonstrated anti-proliferative and anti-invasion activities in various cancer cells.
Guanghui Chen, Yan Yue, Jun Qin, Xinping Xiao, Qing Ren, Bin Xiao   +5 more
doaj   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Theranostic studies of human sodium iodide symporter imaging and therapy using 188Re: a human glioma study in mice. [PDF]

PLoS ONE, 2014
To investigate the role of 188Re in human sodium iodide symporter (hNIS) theranostic gene-mediated human glioma imaging and therapy in model mice.The human glioma cell line U87 was transfected with recombinant lentivirus encoding the hNIS gene under the ...
Rui Guo, M Zhang, Yun Xi, Yufei Ma, Sheng Liang, Shuo Shi, Ying Miao, Biao Li   +7 more
doaj   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a

Molecular Medicine Reports, 2015
Mutations in isocitrate dehydrogenase 1 (IDH1) are found in >70% of secondary glioblastomas and lower-grade gliomas (grades II–III). Among the numerous phenotypic differences between IDH1 mutant and wild-type glioma patients, the most salient is an improved survival rate for patients with a mutation. MicroRNAs (miRNAs) are a class of small, non-coding,
NIE, QUAN-MIN, LIN, YING-YING, YANG, XI, SHEN, LIN, GUO, LIE-MEI, QUE, SHUANG-LIN, LI, XIAO-XIONG, GE, JIAN-WEI, WANG, GUI-SONG, XIONG, WEN-HAO, GUO, PIN, QIU, YONG-MING   +11 more
openaire   +2 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 270-284, February 2026.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Dihydroartemisinin suppresses cell proliferation, invasion, and angiogenesis in human glioma U87 cells

African Journal of Pharmacy and Pharmacology, 2012
Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, which is a well tolerated and effective drug for malaria treatment, has shown potent antitumor ability. This study is explored to evaluate whether DHA can inhibit glioma cell proliferation, invasion, and glioma cell mediated angiogenesis.
openaire   +1 more source