Results 81 to 90 of about 15,914 (183)
Biology DirectBackground Glioma is a common tumor that occurs in the brain and spinal cord. Hypoxia is a crucial feature of the tumor microenvironment. Tumor-associated macrophages/microglia play a crucial role in the advancement of glioma.
Jinchao Si +6 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background The Hedgehog (Hh) signaling pathway plays critical roles in modulating embryogenesis and maintaining tissue homeostasis, with glioma-associated oncogene (GLI) transcription factors being the main mediators.
Dengliang Huang +8 more
doaj +1 more source
Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Shriya Makam, Hana M. Dobrovolny
wiley +1 more source
Cancer Science, Volume 117, Issue 2, Page 445-455, February 2026.In this study, we focused on SUMOylation, a posttranslational modification, and investigated the importance of its consensus sequence in MAFK. We demonstrated that the non‐SUMOylation mimic mutant MAFK (EA) impairs MAFK‐induced EMT, cellular migration and invasion, tumor and sphere formation, acquisition of stem‐like properties, and drug resistance ...
Thuy Linh Dang Cao +7 more
wiley +1 more source
Curcumin Enhances the Radiosensitivity of U87 Cells by Inducing DUSP-2 Up-Regulation
Cellular Physiology and Biochemistry, 2015 Objective: Glioblastoma multiforme (GBM), an aggressive primary brain tumor, is radioresistant and recurs despite aggressive surgery, chemotherapy, and radiotherapy.
Yu Qian +9 more
doaj +1 more source
Sugiol Suppresses the Proliferation of Human U87 Glioma Cells via Induction of Apoptosis and Cell Cycle Arrest. [PDF]
Evid Based Complement Alternat Med, 2022 Alharthy SA +6 more
europepmc +1 more source
GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway
Frontiers in GeneticsBackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Shao Xie +5 more
doaj +1 more source
Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of TAS102 on the proliferation of α-thalassemia mental retardation X-linked (ATRX)-deficient U87 glioma cells in vitro and explore the mechanism. Methods Wild-type glioma U87 cells and ATRX knockout U87 cells (U87ATRX-/
WANG Long +4 more
doaj +1 more source
International Journal of Molecular Medicine, 2018 Photodynamic therapy (PDT) is a relatively novel type of tumor therapy method with low toxicity and limited side‑effects. The aim of the present study was to investigate the underlying mechanism and potential microRNAs (miRNAs) involved in the treatment of glioma by PDT with hematoporphyrin, a clinical photosensitizer.
Shi-Xiang, Yuan +8 more
openaire +3 more sources
Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells
Cellular & Molecular Biology Letters, 2017 Background Gliomas are commonly malignant tumors that arise in the human central nervous system and have a low overall five-year survival rate. Previous studies reported that several members of Rab GTPase family are involved in the development of glioma,
Jian Ge +5 more
doaj +1 more source